Evaluasi Implementasi Manajemen Stratejik Dengan Menggunakan Manajemen Berdasarkan Tujuan (MBO) Pada PT Beta Medical Sebagai Perusahaan Alat Kesehatan

This study aims to determine the results of the evaluation of the implementation of strategies that have been implemented so far using Management by Objectif (MBO). This research was conducted at PT Beta Medical as a Medical Device Company in Indonesia. MBO is used in this study as an analytical tool because this company is a family company and this company is not so complex and not large-scale, only being the sole and non-single distributor of medical devices imported from the manufacturing countries. So to achieve this goal, this study uses a descriptive qualitative approach. Data collection techniques were carried out through interviews, observations, and documentation studies. Data analysis procedures are data reduction, data display, and verification. While the research subject is Mr. Andre Marthino, B.Mgt, MIB as the Marketing Director at PT Beta Medical and also as the son of the owner of the company PT Beta Medical, namely Mr. Drs. Ec. Amiruddin M. Noer, MBA. The results of this study indicate that the implementation of the strategy that has been implemented by PT Beta Medical is still very ineffective because the targets set by the company have not been achieved for the last two years. Most likely in the following year it will not be achieved. All of this can happen because the implementation process is not so good, clear and focused on each division which results in many obstacles and problems faced by the company

PENGARUH PERTUMBUHAN PEMBIAYAAN MUDHARABAH, MUSYARAKAH, DAN DANA PIHAK KETIGA TERHADAP PROFITABILITAS (ROA)

Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh pertumbuhan pembiayaan mudharabah, musyarakah dan dana pihak ketiga terhadap profitabilitas (ROA). Studi kasus pada Bank Umum Syariah di Indonesia sebelum bergabung menjadi Bank Syariah Indonesia (BSI), yaitu pada Bank Mega Syariah,  Bank Panin Dubai Syariah, Bank Muamalat Indonesia Tbk, Bank BNI Syariah, Bank BRI Syariah dan Bank Syariah Mandiri. Penelitian ini menggunakan sampel 6 perusahaan Bank dengan tahun penelitian 2012-2020. Sumber data yang diperoleh dari laporan keuangan tahunan (neraca dan laba rugi). Metode penelitian yang digunakan adalah analisis regresi data panel. Hasil dari penelitian ini menunjukkan bahwa; (1) Variabel pertumbuhan pembiayaan mudharabah berpengaruh negatif signifikan terhadap profitabilitas (ROA), (2) Variabel pertumbuhan pembiyaan musyarakah berpengaruh positif tidak signifikan terhadap profitabilitas (ROA), (3) Variabel pertumbuhan dana pihak ketiga mempengaruhi profitabilitas (ROA). Uji simultan (uji F) menunjukkan variable pertumbuhan pembiayaan mudharabah, musyarakah dan dana pihak ketiga mempengaruhi profitabilitas (ROA) secara positif signifikan secara simultan. Uji Determinasi (R2) sebesar 0,9376 atau 93,76% pada level of significant 5%

Century Enterprise: Pee-Cut Machine / Muhammad Aniq Hazman Hairozie ...[et al.]

Century Enterprise offers a product that combines two functions in a machine which are peeling and cutting. By this combination, Pee-Cut Portable Machine was made as an idea to ease people's activities in daily life. Household areas is a place that was surveyed which 63.6% from 70 respondents facing difficulties in cutting and peeling fruit for their daily uses. The major problem is the difficulty in peeling and cutting manually which is tiring and taking your time if you are inexperienced. Next, sharp tools as knives that were used in cutting and peeling can also give harms to people where danger is everywhere. So, by combining peeling and cutting, those difficulties are slowly will be easier and dangers can be avoided

Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain

BACKGROUND: Exposure to the chemotherapeutic alkylating agent thiotepa during brain development leads to neurological complications arising from neurodegeneration and irreversible damage to the developing central nerve system (CNS). Administration of single dose of thiotepa in 7-d postnatal (P7) rat triggers activation of apoptotic cascade and widespread neuronal death. The present study was aimed to elucidate whether nicotinamide may prevent thiotepa-induced neurodegeneration in the developing rat brain. METHODOLOGY/PRINCIPAL FINDINGS: Neuronal cell death induced by thiotepa was associated with the induction of Bax, release of cytochrome-c from mitochondria into the cytosol, activation of caspase-3 and cleavage of poly (ADP-ribose) polymerase (PARP-1). Post-treatment of developing rats with nicotinamide suppressed thiotepa-induced upregulation of Bax, reduced cytochrome-c release into the cytosol and reduced expression of activated caspase-3 and cleavage of PARP-1. Cresyl violet staining showed numerous dead cells in the cortex hippocampus and thalamus; post-treatment with nicotinamide reduced the number of dead cells in these brain regions. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) and immunohistochemical analysis of caspase-3 show that thiotepa-induced cell death is apoptotic and that it is inhibited by nicotinamide treatment. CONCLUSION: Nicotinamide (Nic) treatment with thiotepa significantly improved neuronal survival and alleviated neuronal cell death in the developing rat. These data demonstrate that nicotinamide shows promise as a therapeutic and neuroprotective agent for the treatment of neurodegenerative disorders in newborns and infants

Mediasi Return On Equity Pengaruh Struktur Modal Terhadap Harga Saham

Harga saham perubahannya ditentukan oleh ROE (Return on Equity), sedangkan ROE itu sendiri naik turunnya ditentukan oleh struktur modal, maka tujuan dari penelitian ini untuk mengevaluasi pengaruh Struktur Modal terhadap Harga Saham dengan mediasi ROE (Return on Equity). Sampel sebanyak 16 saham yang dipilih dari 27 saham Sub Sektor Perdagangan Eceren yang terdaftar di Bursa Efek Indonesia (BEI) periode tahun 2015-2020 dengan metode purposive sampling. Metode analisis digunakan dengan regresi data panel random effect dengan Path Analysis. Hasil penelitian menunjukan Struktur Modal berpengaruh negatif signifikan terhadap Harga Saham, Struktur Modal berpengaruh positif signifikan terhadap Harga Saham dengan mediasi ROE. Penelitian ini merupakan pengembangan yang mengeksplorasi analisis yang melibatkan variabel mediasi ROE untuk melihat pengaruh struktur modal dengan harga saham dalam lingkup Sub Sektor Perdagangan Eceran di Bursa Efek Indonesia, sehingga dapat memberikan tambahan referensi secara akademis. Secara praktis, hasil penelitian ini dapat memberikan manfaat bagi investor yang berinvestasi di pasar modal