Figures S1 - S9 from BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer

Figure S1. Inducible BMX knockdown suppresses CWR22RV1 tumor growth in vitro and in vivo; Figure S2. Schematic picture of BMX signaling pathway; Figure S3. The effect of BMX SiRNA smart pool on CWR22RV1 cell response to serum stimulation; Figure S4. The specificity of BMX antibody; Figure S5. Affymetrix microarray expression of BMX in PCa patients; Figure S6. BMX mRNA expression is repressed by DHT; Figure S7. BMX knockdown in CWR22RV1 cells; Figure S8. AR binding site sequence in BMX loci; Figure S9. DHT effect on expression of AR and associated proteins.</p

Supplementary Data from A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes

Supplementary Data from A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Gene

Supplementary Figure S4 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

FASN gene expression is upregulated and FASN gene is hypomethylated in primary prostate tumors from the NCI primary tumor cohort.</p

FIGURE 5 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

FASN protein expression is increased in prostate tumors from germline HOXB13 G84E carriers compared with matched WT controls. A, FASN protein expression by immunostaining is higher in HOXB13 G84E carriers than matched HOXB13 WT controls. B, ERG status is not associated with FASN protein expression among HOXB13 G84E carriers, though higher expression is seen among ERG-positive compared with ERG-negative tumors from HOXB13 WT controls (****, P < 0.0001).</p

Supplementary Figure S7 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

FASN gene expression and methylation is significantly associated with ERG status in TCGA primary tumor cohort.</p

FIGURE 6 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Neither FASN protein, nor FASN gene methylation are associated with self-identified race. A, FASN protein expression by race in JHU primary tumor cohort. B, FASN protein expression by race in PCBN primary tumor cohort. C, FASN protein expression by race in TCGA primary tumor cohort. D,FASN gene expression by race in TCGA primary tumor cohort. E,FASN gene methylation mean beta value by self-identified race in JHU primary tumor cohort. F,FASN gene methylation mean beta value by self-identified race in TCGA primary tumor cohort (*, P < 0.05).</p

Supplementary Tables S1-S7 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Supplementary Tables S1-S7</p

Supplementary Figure S2 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Digital quantification of FASN immunostaining in prostate tumor cells</p

Supplementary Data from Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Supplementary Data from Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cance

FIGURE 3 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

FASN protein expression in tumor glands is inversely correlated with FASN gene methylation in tumor tissue in metastatic CRPC cohort. A, Representative plots of CpG methylation level in FASN by WGBS with corresponding FASN mRNA expression (TPM) for three representative tumors with low (blue) and high (red) FASN gene expression in the SU2C WCDT cohort. Mean FASN CpG methylation level is negatively correlated with FASN mRNA expression in the SU2C WCDT samples; each point represents an individual tumor in B.</p