6 research outputs found

    Sinonasal Teratocarcinosarcoma

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    Sinonasal Teratocarcinosarcoma (SNTCS) is an extremely rare and unusual malignant neoplasm of the sinonasal tract with an aggressive behaviour. Till date, there are less than a hundred cases reported in literature. A 52 year old patient presented with a large, reddish brown, right sided nasal mass with epistaxis since 1 month. Histopathology revealed a highly malignant tumor with diverse histomorphological features and was labelled SNTCS. These unique tumors show diverse histomorphological features of a carcinosarcoma with teratoid elements. Immunohistochemistry was positive for cytokeratin, vimentin, GFAP, NSE, S-100. Chemotherapy with cisplatin and etoposide was given followed by a debulking surgery. The patient is well seven months after diagnosis and scheduled for radiotherapy. Diagnosis of SNTCS requires an adequate representative biopsy and extensive sampling on Histopathology. Treatment required included surgery, chemotherapy and radiotherapy

    MXene (Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>)-Embedded Nanocomposite Hydrogels for Biomedical Applications: A Review

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    Polymeric nanocomposites have been outstanding functional materials and have garnered immense attention as sustainable materials to address multi-disciplinary problems. MXenes have emerged as a newer class of 2D materials that produce metallic conductivity upon interaction with hydrophilic species, and their delamination affords monolayer nanoplatelets of a thickness of about one nm and a side size in the micrometer range. Delaminated MXene has a high aspect ratio, making it an alluring nanofiller for multifunctional polymer nanocomposites. Herein, we have classified and discussed the structure, properties and application of major polysaccharide-based electroactive hydrogels (hyaluronic acid (HA), alginate sodium (SA), chitosan (CS) and cellulose) in biomedical applications, starting with the brief historical account of MXene’s development followed by successive discussions on the synthesis methods, structures and properties of nanocomposites encompassing polysaccharides and MXenes, including their biomedical applications, cytotoxicity and biocompatibility aspects. Finally, the MXenes and their utility in the biomedical arena is deliberated with an eye on potential opportunities and challenges anticipated for them in the future, thus promoting their multifaceted applications

    Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

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    Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made significant changes in fabrication techniques for microneedles (MNs) and design shifted from conventional to novel, using various types of natural and synthetic materials and their combinations. Nowadays, MNs technology has gained popularity worldwide in biomedical research and drug delivery technology due to its multifaceted and broad-spectrum applications. This review broadly discusses MN&rsquo;s types, fabrication methods, composition, characterization, applications, recent advancements, and global intellectual scenarios