Listen to the Companies: Exploring BIM Job Competency Requirements by Text Mining of Recruitment Information in China

Building information modeling (BIM) is a pivotal technology to realizing the digital transformation of the construction industry. Lack of BIM professionals, however, is one of the reasons the application of BIM technology in the construction industry is hindered. Identifying BIM competency requirements is critical for BIM professionals' training. This paper uses the structural topic model (STM) to mine the topics of BIM recruitment information to deeply understand the BIM competency requirements from a 360° view of the construction industry. The company size, salary level, year of experience, and education in BIM recruitment information are taken as covariates to examine their impact on BIM recruitment topic prevalence. And the changing trend of the topic prevalence and topic correlations are observed through visual analysis. The results reveal that the current BIM competency requirements in the construction industry contain three aspects: management competencies, professional and technical competencies, and personal characteristics. In particular, the requirements for BIM application, construction drawing design, and information technology (IT) skills are relatively strong, and personnel professionalism is also a concern of BIM job recruitment. Companies of different sizes have evident preferences for competencies. Salary levels and years of experience requirements also affect the intensity of corporate demand for BIM competencies. However, education is not the main factor affecting the recruitment of BIM positions. The results can provide a reliable theoretical basis for educational institutions to build a proper BIM professional course system, for companies to develop BIM job recruitment plans, and for individuals to choose their employment goals

Kendig's Disorders of the Respiratory Tract in Children, Ninth Edition

Now in a fully updated 9th Edition, Kendig's Disorders of the Respiratory Tract in Children, by Drs. Robert Wilmott, Andrew Bush, Robin Deterding, Felix Ratjen, Peter Sly, Heather Zar and Albert P. Li continues to provide authoritative, evidence-based information to residents, fellows, and practitioners in this wide-ranging specialty. Bringing key knowledge from global experts together in one easy-to-understand volume, it covers everything from the latest basic science and its relevance to today’s clinical issues, to improving patient outcomes for the common and rare respiratory problems found in newborns and children worldwide

A colorimetric and fluorometric dual-mode probe for Cu²⁺detection based on functionalized silver nanoparticles

A novel colorimetric/fluorescent probe (AgNPs-GSH-Rh6G2) was prepared by linking silver nanoparticles (AgNPs) with rhodamine 6G derivative (Rh6G2) using glutathione (GSH) as a linker molecule. The prepared probe showed obvious fluorescence change and colorimetric response after adding copper ions. Based on this phenomenon, a colorimetric/fluorescence dual-mode detection method was constructed to recognize copper ions. The linear ranges of fluorescence detection and colorimetric detection were 0.10 to 0.45 mM and 0.15 to 0.65 mM, respectively, and the limit of detection were 0.18 μM and 24.90 μΜ. In addition, the dual-mode probe has achieved satisfactory results in the detection of copper ions in sediment samples. The successful construction of AgNPs-GSH-Rh6G2 not only provide a reliable tool for the detection of copper ions, but also shed light on a new idea for the multi-mode development of the detection platform

A colorimetric and fluorometric dual-mode probe for Cu²⁺detection based on functionalized silver nanoparticles

A colorimetric and fluorometric dual-mode probe for Cu2+detection based on functionalized silver nanoparticle

A prognostic model of drug tolerant persister-related genes in lung adenocarcinoma based on single cell and bulk RNA sequencing data

Background: Acquired resistance to targeted drugs is a major challenge in cancer. The drug-tolerant state has been proposed to be an initial step towards acquisition of real drug-resistance. Drug tolerant persister (DTP) cells are purported to survive during treatment and stay dormant for several years. Single cell sequencing can provide a comprehensive landscape of gene expression in DTP cells, which can facilitate investigation of heterogeneity of a drug tolerant state and identification of new anticancer targets. Methods: The genetic profiling of DTPs was explored by integrating Gene Expression Omnibus (GEO) datasets, and a prognostic signature of DTP-related genes (DTPRGs) in lung adenocarcinoma of TCGA LUAD cohort was constructed. The scores of infiltrating immune cells were calculated and activity of immune-related pathways was evaluated by single-sample gene set enrichment analysis (ssGSEA). Functional enrichment analysis of the DTPRGs between low- and high-risk groups was performed. Immune cell subtypes and immune-related pathways were analyzed. Results: An 11-gene panel (MT2A, UBE2S, CLTB, KRT7, IGFBP3, CTSH, NPC2, HMGA1, HNRNPAB, DTYMK, and IHNA) was established. DTPRGs were mainly correlated with nuclear division, chromosome segregation, and cell cycle pathways. Infiltration of immune cells was lower in the high-risk group while the inflammation-promoting and MCH-class I response pathway had higher activity in the high-risk group. A nomogram was generated with prognostic accuracy, further validated using clinical outcomes following therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). Discussion: A prognostic model of lung adenocarcinoma based on DTPRGs was constructed. Targeting DTP cells is a potential therapeutic approach to prevent a drug tolerant state.</p

Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies

Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come from their paracrine signalling, i.e. secreted factors such as cytokines, chemokines, and extracellular vesicles (EVs). Cell-free therapy using EVs is an active and emerging field in regenerative medicine. Typical 2D cultures on tissue culture plastic is far removed from the physiological environment of MSCs. The application of 3D cell culture allows MSCs to adapt to their cellular environment which, in turn, influences their paracrine signalling activity. In this study we evaluated the impact of 3D MSCs culture on EVs secretion, cargo proteome composition, and functional assessment in immunomodulatory, anti-inflammatory and anti-fibrotic properties. MSC-EVs from 2D and 3D cultures expressed classical EV markers CD81, CD63, and CD9 with particle diameter of <100 nm. There were distinct changes in immunomodulatory potencies where 3D cultures exhibited reduced indoleamine 2,3-dioxygenase (IDO) activity and significantly reduced macrophage phagocytosis. Administration of 2D and 3D EVs following double dose bleomycin challenge in aged mice showed a marked increase of bodyweight loss in 3D group throughout days 7–28. Histopathological observations of lung tissues in 3D group showed increased collagen deposition, myofibroblast differentiation and leukocytes infiltrations. Assessment of lung mechanics showed 3D group did not improve lung function and instead exhibited increased resistance and tissue damping. Proteome profiling of MSC-EV composition revealed molecular enrichment of EV markers (compared to parental cells) and differential proteome between EVs from 2D and 3D culture condition associated with immune-based and fibrosis/extracellular matrix/membrane organization associated function. This study provides insight into distinct variation in EV protein composition dependent on the cellular microenvironment of the parental cells, which could have implications in their therapeutic effect and potency. Overall, this work suggests that EVs produced from 3D MSC cultures did not enhance typical MSC-EV properties expected from 2D cultures (immunomodulation, anti-fibrotic, anti-inflammatory). The outcome highlights critical differences between MSC-EVs obtained from different culture microenvironments, which should be considered when scaling up MSC culture for clinical manufacturing

GOTO065054+593624: An 8.5 mag amplitude dwarf nova identified in real time via Kilonova Seekers

Dwarf novae are astrophysical laboratories for probing the nature of accretion, binary mass transfer, and binary evolution, but their diverse observational characteristics continue to challenge our theoretical understanding. We here present the discovery of and subsequent observing campaign on GOTO065054+593624 (hereafter GOTO0650), a dwarf nova of the WZ Sge type that was discovered in real-time by citizen scientists via the Kilonova Seekers citizen science project. The nova has an outburst amplitude of 8.5 mag. An extensive dataset charts the photometric and spectroscopic evolution of this object, and it covers the 2024 superoutburst. GOTO0650 shows an absence of visible emission lines during the high state, strong H and barely detected He II emission, and high-amplitude echo outbursts on a rapidly decreasing timescale. The comprehensive dataset we present marks GOTO0650 as a candidate period bouncer, and it highlights the important contribution made by citizen scientists to the study of Galactic transients.</p

Integrated and differential fiducial cross-section measurements for the vector boson fusion production of the Higgs boson in the H →WW∗→eνμν decay channel at 13 TeV with the ATLAS detector

The vector-boson production cross section for the Higgs boson decay in the Formula Presented channel is measured as a function of kinematic observables sensitive to the Higgs boson production and decay properties as well as integrated in a fiducial phase space. The analysis is performed using the proton-proton collision data collected by the ATLAS detector in Run 2 of the LHC at Formula Presented center-of-mass energy, corresponding to an integrated luminosity of Formula Presented. The different flavor final state is studied by selecting an electron and a muon originating from a pair of Formula Presented bosons and compatible with the Higgs boson decay. The data are corrected for the effects of detector inefficiency and resolution, and the measurements are compared with different state-of-the-art theoretical predictions. The differential cross sections are used to constrain anomalous interactions described by dimension-six operators in an effective field theory.</p

Azimuthal Angle Correlations of Muons Produced via Heavy-Flavor Decays in 5.02 TeV Pb+Pb and pp Collisions with the ATLAS Detector

Angular correlations between heavy quarks provide a unique probe of the quark-gluon plasma created in ultrarelativistic heavy-ion collisions. Results are presented of a measurement of the azimuthal angle correlations between muons originating from semileptonic decays of heavy quarks produced in 5.02 TeV Formula Presented and Formula Presented collisions at the LHC. The muons are measured with transverse momenta and pseudorapidities satisfying Formula Presented and Formula Presented, respectively. The distributions of azimuthal angle separation Formula Presented for muon pairs having pseudorapidity separation Formula Presented, are measured in different Formula Presented centrality intervals and compared to the same distribution measured in Formula Presented collisions at the same center-of-mass energy. Results are presented separately for muon pairs with opposite-sign charges, same-sign charges, and all pairs. A clear peak is observed in all Formula Presented distributions at Formula Presented, consistent with the parent heavy-quark pairs being produced via hard-scattering processes. The widths of that peak, characterized using Cauchy-Lorentz fits to the Formula Presented distributions, are found to not vary significantly as a function of Formula Presented collision centrality and are similar for Formula Presented and Formula Presented collisions. This observation will provide important constraints on theoretical descriptions of heavy-quark interactions with the quark-gluon plasma.</p

Search for Nearly Mass-Degenerate Higgsinos Using Low-Momentum Mildly Displaced Tracks in pp Collisions at Formula Presented with the ATLAS Detector

Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is Formula Presented. This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse impact parameter using Formula Presented of proton-proton collision data at Formula Presented collected by the ATLAS experiment. For the first time since LEP, a range of mass splittings between the lightest charged and neutral Higgsinos from 0.3 to 0.9 GeV is excluded at 95% confidence level, with a maximum reach of approximately 170 GeV in the Higgsino mass.</p