635 research outputs found

    Amine impregnated porous silica gel sorbents synthesized from water-glass precursors for CO2 capturing

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    In this work, porous silica gel-solid beads have been made from economically affordable water-glass precursors via sol-gel nano casting technique. A stable nanometric silica sol was prepared first from water glass and studied for surface potential and sol to gel transition. A free-flow, injectable gel was obtained upon aging the sol which was then assembled into spherical silica beads in a chemical bath. A surface area of 304.7m2g-1 was obtained for water glass derived silica gel beads. These gel beads were impregnated with 3-aminopropyltrimethoxysilane (APTMS) and polyethylenimine (PEI) active functional groups at different percentages for turning the gel beads as sorbents for CO2 gas adsorption. The effect of amine loading on the thermal stability, morphology as well as porosity was studied and was correlated with CO2 adsorption values. Depending upon the amount of amine loaded in the gel support CO2 uptake was found varied. These amine modified silica gel porous adsorbents showed CO2 adsorption capacity at temperatures as low as 100°C; samples modified with 15wt% PEI had CO2 adsorption capacity of 1.16mmolg-1 at 50°C. © 2015 Elsevier B.V

    ORMOSIL–ZrO2 hybrid nanocomposites and coatings on aluminium alloys for corrosion resistance; A sol-gel approach

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    Corrosion resistant coatings are prepared from a hybrid nanocomposite aerogel derived from tri-functional silanes, methyltrimethoxysilane (MTMS) and glycidyloxypropyl trimethoxysilane (GPTMS) and from a zirconium isopropoxide (ZIP) precursor which acts as an inorganic nano-dispersion in an organically modified silane (ORMOSIL) matrix. A series of hybrid compositions of MTMS and GPTMS are prepared in which the amount of ZIP is varied. The variations in the pH, viscosity and gelation time of the prepared compositions are monitored. The wet alcogels thus obtained are homogenized in a solvent using an ultrasonicator followed by coating the suspension on aluminium alloys and glass substrates using a dip coating unit. The prepared coatings are further dried and annealed at 400 °C for 1 h. The wet alcogels are also dried under ambient conditions for seven days resulting in hybrid nanocomposite aerogel monoliths and are calcined at 400 °C. The hybrid nanocomposites and coatings are further characterized using X-ray diffraction analysis, Fourier transform infrared spectroscopy, BET surface area analysis, X-ray photoelectron spectroscopy, scanning electron microscopy (SEM), atomic force microscopy (AFM), UV-visible spectroscopy, potentiodynamic polarization and EIS measurements. The hybrid nanocomposite coated aluminium alloy shows enhanced corrosion protection when compared to the uncoated aluminium alloy. The anticorrosive feature of the ORMOSIL-ZrO2hybrid nanocomposite coatings makes them an important candidate in the field of protective environment resistant coatings

    Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations

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    Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS-ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution. © 2015 The Royal Society of Chemistry

    Macrophage Pro-Inflammatory Response to Francisella novicida Infection Is Regulated by SHIP

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    Francisella tularensis, a Gram-negative facultative intracellular pathogen infecting principally macrophages and monocytes, is the etiological agent of tularemia. Macrophage responses to F. tularensis infection include the production of pro-inflammatory cytokines such as interleukin (IL)-12, which is critical for immunity against infection. Molecular mechanisms regulating production of these inflammatory mediators are poorly understood. Herein we report that the SH2 domain-containing inositol phosphatase (SHIP) is phosphorylated upon infection of primary murine macrophages with the genetically related F. novicida, and negatively regulates F. novicida–induced cytokine production. Analyses of the molecular details revealed that in addition to activating the MAP kinases, F. novicida infection also activated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in these cells. Interestingly, SHIP-deficient macrophages displayed enhanced Akt activation upon F. novicida infection, suggesting elevated PI3K-dependent activation pathways in absence of SHIP. Inhibition of PI3K/Akt resulted in suppression of F. novicida–induced cytokine production through the inhibition of NFκB. Consistently, macrophages lacking SHIP displayed enhanced NFκB-driven gene transcription, whereas overexpression of SHIP led to decreased NFκB activation. Thus, we propose that SHIP negatively regulates F. novicida–induced inflammatory cytokine response by antagonizing the PI3K/Akt pathway and suppressing NFκB-mediated gene transcription. A detailed analysis of phosphoinositide signaling may provide valuable clues for better understanding the pathogenesis of tularemia

    Relationship between cortisol and physical performance in older persons

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    Objective: Hypercortisolism is associated with muscle weakness. This study examines the relationship between cortisol and physical performance in older persons. Design/patients: The study was conducted within the Longitudinal Aging Study Amsterdam (LASA), an ongoing cohort study in a population-based sample of healthy older persons in the Netherlands. Data from the second (1995/1996) and fourth (2001/2002) cycle were used pertaining to 1172 (65-88 years) and 884 (65-94 years) men and women, respectively. Measurements: Physical performance was measured by adding up scores on the chair stands, tandem stand and walk test (range 0-12). In the second cycle serum total and calculated free cortisol were assessed; in the fourth cycle evening salivary cortisol was assessed. Regression analysis (stratified for sex, adjusted for age, body mass index, alcohol use, physical activity and region) was performed to examine the cross-sectional relationship between cortisol and physical performance. Results: Women with higher calculated free cortisol scored less well on physical performance (b = -0.28 per SD higher cortisol, P = 0.016), which was mainly explained by poorer performance on the tandem stand (OR = 1.32 for a lower score per SD higher cortisol, P = 0.003). Men with higher salivary cortisol scored less well on physical performance (b = -0.90 in the highest vs. the lowest quartile, P = 0.008), which was mainly explained by poorer performance on the chair stands and walk test (OR = 1.88, P = 0.020 and OR = 1.81, P = 0.027, respectively, in the highest vs. the lowest quartile). Conclusion: Physical performance is negatively associated with high cortisol levels in older persons. © 2007 The Authors

    Velocity independent constraints on spin-dependent DM-nucleon interactions from IceCube and PICO

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    [EN] Adopting the Standard Halo Model (SHM) of an isotropic Maxwellian velocity distribution for dark matter (DM) particles in the Galaxy, the most stringent current constraints on their spin-dependent scattering cross-section with nucleons come from the IceCube neutrino observatory and the PICO-60 C3F8 superheated bubble chamber experiments. The former is sensitive to high energy neutrinos from the self-annihilation of DM particles captured in the Sun, while the latter looks for nuclear recoil events from DM scattering off nucleons. Although slower DM particles are more likely to be captured by the Sun, the faster ones are more likely to be detected by PICO. Recent N-body simulations suggest significant deviations from the SHM for the smooth halo component of the DM, while observations hint at a dominant fraction of the local DM being in substructures. We use the method of Ferrer et al. (JCAP 1509: 052, 2015) to exploit the complementarity between the two approaches and derive conservative constraints on DM-nucleon scattering. Our results constrain sigma SD less than or similar to 3x10-39cm2 (6x10-38cm2) at greater than or similar to 90% C.L. for a DM particle of mass 1 TeV annihilating into tau+tau- (bb) with a local density of rho DM=0.3GeV/cm3. The constraints scale inversely with rho DM and are independent of the DM velocity distribution.Aartsen, MG.; Ackermann, M.; Adams, J.; Aguilar, JA.; Ahlers, M.; Ahrens, M.; Alispach, C.... (2020). Velocity independent constraints on spin-dependent DM-nucleon interactions from IceCube and PICO. The European Physical Journal C. 80(9):1-8. https://doi.org/10.1140/epjc/s10052-020-8069-5S18809F. Ferrer, A. Ibarra, S. Wild, JCAP 1509(09), 052 (2015). arXiv:1506.03386 [hep-ph]S. van den Bergh, Publ. Astron. Soc. Pac. 111, 657 (1999). arXiv:astro-ph/9904251G. Bertone, D. Hooper, J. Silk, Phys. Rept. 405, 279 (2005). arXiv:hep-ph/0404175A.K. Drukier, K. Freese, D.N. Spergel, Phys. Rev. D 33, 3495 (1986)M. Kuhlen, N. Weiner, J. Diemand, P. Madau, B. Moore, D. Potter, J. Stadel, M. Zemp, JCAP 1002, 030 (2010). arXiv:0912.2358 [astro-ph.GA]M. Lisanti, L.E. Strigari, J.G. Wacker, R.H. Wechsler, Phys. Rev. D 83, 023519 (2011). arXiv:1010.4300 [astro-ph.CO]Y.Y. Mao, L.E. Strigari, R.H. Wechsler, H.Y. Wu, O. Hahn, Astrophys. J. 764, 35 (2013). arXiv:1210.2721 [astro-ph.CO]L. Necib, M. Lisanti, V. Belokurov, arXiv:1807.02519 [astro-ph.GA]N.W. Evans, C.A.J. O’Hare, C. McCabe, Phys. Rev. D 99(2), 023012 (2019). arXiv:1810.11468 [astro-ph.GA]M.G. Aartsen et al. [IceCube Collaboration], Eur. Phys. J. C 77, no. 3, 146 (2017) arXiv:1612.05949 [astro-ph.HE]C. Amole et al., [PICO Collaboration]. Phys. Rev. Lett. 118(25), 251301 (2017). arXiv:1702.07666 [astro-ph.CO]M.T. Frandsen, F. Kahlhoefer, C. McCabe, S. Sarkar, K. Schmidt-Hoberg, JCAP 1201, 024 (2012). arXiv:1111.0292 [hep-ph]K. Choi, C. Rott, Y. Itow, JCAP 1405, 049 (2014). arXiv:1312.0273 [astro-ph.HE]A. Achterberg et al., [IceCube Collaboration]. Astropart. Phys. 26, 155 (2006). arXiv:astro-ph/0604450R. Abbasi et al. [IceCube Collaboration], Nucl. Instrum. Meth. A 601, 294 (2009) arXiv:0810.4930 [physics.ins-det]M.G. Aartsen et al. [IceCube Collaboration], JINST 12, no. 03, P03012 (2017) arXiv:1612.05093 [astro-ph.IM]R. Abbasi et al., [IceCube Collaboration]. Astropart. Phys. 35, 615 (2012). arXiv:1109.6096 [astro-ph.IM]G.J. Feldman, R.D. Cousins, Phys. Rev. D 57, 3873 (1998). https://doi.org/10.1103/PhysRevD.57.3873. arXiv:physics/9711021 [physics.data-an]M. Tanabashi et al. [Particle Data Group], Phys. Rev. D 98, no. 3, 030001 (2018)C. Amole et al. [PICO Collaboration], arXiv:1905.12522 [physics.ins-det]C. Amole et al. [PICO Collaboration], Phys. Rev. D 93, no. 5, 052014 (2016) arXiv:1510.07754 [hep-ex]E. Tollerud et al. [ERFA] Computational Science and Discovery, no 8, 1 (2015) https://doi.org/10.5281/zenodo.1021149J.N. Bahcall, R.K. Ulrich, Rev. Mod. Phys. 60, 297 (1988)T. Mumford et al. [SunPy Community] Computational Science and Discovery, no 8, 1 (2015) arXiv:1505.02563 [astro-ph]V. Gluscevic, M.I. Gresham, S.D. McDermott, A.H.G. Peter, K.M. Zurek, JCAP 1512(12), 057 (2015). arXiv:1506.04454 [hep-ph]A.L. Fitzpatrick, W. Haxton, E. Katz, N. Lubbers, Y. Xu, ‘, JCAP 1302, 004 (2013). https://doi.org/10.1088/1475-7516/2013/02/004. arXiv:1203.3542 [hep-ph]A. Ibarra, A. Rappelt, JCAP 1708(08), 039 (2017). arXiv:1703.09168 [hep-ph
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