35,038 research outputs found
Effect of vitamin D3 supplement in glycemic control of pediatrics with type 1 diabetes mellitus and vitamin D deficiency
Background: Glycemic control prevents microvascular complications in patients with type I diabetes mellitus such as retinopathy, nephropathy and neuropathy that influences quality of life. Some studies show the immunomodulatory effect of vitamin D in synthesis and secretion of insulin. Aims: In this study we evaluate glycemic changes after vitamin D3 supplement in children with type I diabetes mellitus and vitamin D deficiency. Materials and Methods: In children with type I diabetes mellitus, level of vitamin D and HbA1C was measured. Patients with type I diabetes mellitus who had vitamin D deficiency (25OHD 9.9. This supplement transfer patients toward better glycemic control for the entire group (p-value < 0.0001). Conclusion: Vitamin D3 supplement improves HbA1C in pediatrics with type I diabetes mellitus and vitamin D deficiency. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved
Effect of Vitamin D Deficiency on Gestational Diabetes Mellitus: A Meta-Analysis
Background: Gestational diabetes mellitus increases the risk of a number of short-term and long-term health problems in both mother and baby. Some evidence states that one of the causes of gestational diabetes mellitus is vitamin D deficiency. This study aimed to estimate the magnitude of the influence of vitamin D deficiency on the incidence of gestational diabetes mellitus, through a meta-analysis of previous primary studies.
Subjects and Method: This was a systematic review and meta-analysis with the following PICO, population: pregnant women, intervention: vitamin D deficiency, comparison: no vitamin D deficiency, outcome: gestational diabetes mellitus. The articles used in this study were obtained from four databases, namely PubMed, Google Scholar, Science Direct, and Springer Link, using the search keys "Vitamin D Deficiency"[Mesh] OR “Vitamin D Deficiency”[tw] AND "Diabetes, Gestational" [Mesh] OR “Gestational Diabetes Mellitus”[tw] OR “Gestational Diabetes”[tw]. The included article is a full-text cohort study design from 2018 to 2022 and reports the adjusted odds ratio (aOR) in a multivariate analysis. The selection of articles is done using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.
Results: A total of 9 cohort studies involving 42,972 pregnant women from the continents of Asia, Australia and Europe were used in the meta-analysis. Pregnant women with vitamin D deficiency had a risk of gestational diabetes mellitus 1.87 times compared to those without vitamin D deficiency (aOR= 1.87; 95% CI= 1.27 to 2.75; p= 0.002).
Conclusion: Vitamin D deficiency increases the risk of developing gestational diabetes mellitus.
Keywords: vitamin D deficiency, gestational diabetes mellitus, pregnancy
Correspondence:Dian Handayani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57126, Central Java, Indonesia. Email: [email protected]. Mobile: +6285876686231
The Association between Vitamin D Deficiency and the Prognosis of Type 2 Diabetes Mellitus
Introduction: Type 2 diabetes mellitus is a prevalent chronic disease with high morbidity and mortality, characterized by inadequate cellular response to insulin and insufficient insulin production by pancreatic β-cells. Epidemiological studies indicate that low serum vitamin D levels are prevalent among the general population globally, exacerbating outcomes of many diseases. Recent studies suggest that vitamin D deficiency may impact type 2 diabetes mellitus prognosis. Understanding type 2 diabetes mellitus risk factors and disease progression variables is crucial for proper patient management and public health policies.
Purpose of the work: This study aims to review the relationship between vitamin D deficiency and the prognosis of type 2 diabetes mellitus.
Materials and methods: A comprehensive analysis of research papers available on PubMed, Google Scholar, Web of Science, Embase and Scopus was undertaken using the search terms encompassing the following keywords: vitamin D insufficiency / vitamin D supplementation / vitamin D2 / vitamin D3 / ergocalciferol / cholecalciferol and type 2 diabetes mellitus / complications of diabetes / hyperglycemia / insulin resistance / glucose metabolism.
Results: Vitamin D deficiency can impact the prognosis of type 2 diabetes mellitus, exacerbating complications associated with chronic hyperglycemia such as obesity, mental health issues, vascular complications, and diabetic neuropathy. Given its prevalence among type 2 diabetes mellitus patients, early screening and supplementation of vitamin D could offer potential benefits
D-vitamin es neuropathia.
Diabetes is a widespread disease and, therefore, studies dealing with diabetes and its complications are very important for public health. Numerous reports link vitamin D deficiency to the increased risk of diabetes mellitus and complications such as neuropathy. However, there are limited and conflicting data available on vitamin D deficiency in patients with diabetic peripheral neuropathy. Studies in type 2 diabetics confirmed the relationship between vitamin D deficiency and incidence of neuropathy. Recent reports suggest a relationship between the incidence of plantar ulcers and vitamin D deficiency. Orv. Hetil., 2013, 154(51), 2012-2015
Effect of Vitamin D Deficiency on Gestational Diabetes Mellitus: A Meta-Analysis
Background: Gestational diabetes mellitus increases the risk of a number of short-term and long-term health problems in both mother and baby. Some evidence states that one of the causes of gestational diabetes mellitus is vitamin D deficiency. This study aimed to estimate the magnitude of the influence of vitamin D deficiency on the incidence of gestational diabetes mellitus, through a meta-analysis of previous primary studies.
Subjects and Method: This was a systematic review and meta-analysis with the following PICO, population: pregnant women, intervention: vitamin D deficiency, comparison: no vitamin D deficiency, outcome: gestational diabetes mellitus. The articles used in this study were obtained from four databases, namely PubMed, Google Scholar, Science Direct, and Springer Link, using the search keys "Vitamin D Deficiency"[Mesh] OR “Vitamin D Deficiency”[tw] AND "Diabetes, Gestational" [Mesh] OR “Gestational Diabetes Mellitus”[tw] OR “Gestational Diabetes”[tw]. The included article is a full-text cohort study design from 2018 to 2022 and reports the adjusted odds ratio (aOR) in a multivariate analysis. The selection of articles is done using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.
Results: A total of 9 cohort studies involving 42,972 pregnant women from the continents of Asia, Australia and Europe were used in the meta-analysis. Pregnant women with vitamin D deficiency had a risk of gestational diabetes mellitus 1.87 times compared to those without vitamin D deficiency (aOR= 1.87; 95% CI= 1.27 to 2.75; p= 0.002).
Conclusion: Vitamin D deficiency increases the risk of developing gestational diabetes mellitus.
Keywords: vitamin D deficiency, gestational diabetes mellitus, pregnancy
Correspondence:
Dian Handayani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57126, Central Java, Indonesia. Email: [email protected]. Mobile: +6285876686231
Effect of Vitamin D Deficiency on Gestational Diabetes Mellitus: A Meta-Analysis
Background: Gestational diabetes mellitus increases the risk of a number of short-term and long-term health problems in both mother and baby. Some evidence states that one of the causes of gestational diabetes mellitus is vitamin D deficiency. This study aimed to estimate the magnitude of the influence of vitamin D deficiency on the incidence of gestational diabetes mellitus, through a meta-analysis of previous primary studies.
Subjects and Method: This was a systematic review and meta-analysis with the following PICO, population: pregnant women, intervention: vitamin D deficiency, comparison: no vitamin D deficiency, outcome: gestational diabetes mellitus. The articles used in this study were obtained from four databases, namely PubMed, Google Scholar, Science Direct, and Springer Link, using the search keys "Vitamin D Deficiency"[Mesh] OR “Vitamin D Deficiency”[tw] AND "Diabetes, Gestational" [Mesh] OR “Gestational Diabetes Mellitus”[tw] OR “Gestational Diabetes”[tw]. The included article is a full-text cohort study design from 2018 to 2022 and reports the adjusted odds ratio (aOR) in a multivariate analysis. The selection of articles is done using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.
Results: A total of 9 cohort studies involving 42,972 pregnant women from the continents of Asia, Australia and Europe were used in the meta-analysis. Pregnant women with vitamin D deficiency had a risk of gestational diabetes mellitus 1.87 times compared to those without vitamin D deficiency (aOR= 1.87; 95% CI= 1.27 to 2.75; p= 0.002).
Conclusion: Vitamin D deficiency increases the risk of developing gestational diabetes mellitus.
Keywords: vitamin D deficiency, gestational diabetes mellitus, pregnancy
Correspondence:
Dian Handayani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57126, Central Java, Indonesia. Email: [email protected]. Mobile: +6285876686231
THE PREVALENCE AND DETERMINANT FACTORS OF LOW VITAMIN D LEVELS IN PATIENTS WITH PAINFUL DIABETIC NEUROPATHY
Objective: Type 2 diabetes mellitus is a major public health problem. Diabetic neuropathy is one of the major diabetes microvascular complications. The previous study suggests that Vitamin D deficiency plays an important role in the development and progression of diabetes and the data in Indonesia are very limited. This study aims to measure the prevalence of Vitamin D deficiency and its determinant factors in patients with painful diabetic neuropathy (PDN).
Methods: This study is a cross-sectional study. The data were obtained from 53 subjects with diabetic peripheral neuropathy. A pre-designed questionnaire was used to collect data on the patient’s age, gender, duration of diabetes, comorbidities, any diabetic complications, and current treatment for diabetes mellitus. The Vitamin D levels were measured by a standardized method in the Prodia Research Laboratory.
Results: Study findings showed that from 53 study subjects, most of them were female (79.2%). The mean age of subjects was 57.83±8.79 years. We found a high prevalence of low Vitamin D levels in the Indonesian population as many as 98.11% and only 1.9% has sufficiency Vitamin D levels. Gender (p=0.028), hypertension (p=0.027), and controlled complications (p=0.005) were significantly associated with Vitamin D levels.
Conclusion: All patients with PDN in this study had a high prevalence of Vitamin D deficiency. This high prevalence of Vitamin D deficiency also has been reported worldwide. Physician should be aware and continue to treat patients with Vitamin D deficiency
A case control study to determine the role of vitamin D in the risk of coronary artery disease among type 2 diabetic individuals
Background: Diabetes Mellitus comprises a group of metabolic disorder leading to hyperglycaemia. Vitamin D deficiency plays a role in Type 2 Diabetes Mellitus pathogenesis. Vitamin D appears to affect several metabolisms that have been associated with coronary artery disease. Vitamin D level has been recently considered as an adjustable risk factor of cardiovascular diseases, in individuals with type 2 Diabetes.Methods: This case control study was conducted in the Department of Medicine, UPUMS. 100 diabetic individuals with low Vitamin D level were taken as cases and 100 diabetic individuals with normal vitamin D level as control. History and examination with necessary investigations were done. Patients with positive history were subjected to investigations to diagnose CAD.Results: The proportion of case and controls had no significant difference in age distribution. The risk of coronary artery disease was 2.76 times higher among diabetes mellitus patients with vitamin D deficiency (1.36-5.59). The risk of CAD was adjusted for various risk factors (age, sex, hypertension, smoking, physical activity, and lipid profile) Odds ratio was found to be 2.8 (95% CI-1.19-6.94, p-0.018).Conclusions: Vitamin D deficiency among diabetes patients was found to be an independent risk factor for CAD after adjusting other risk factors emphasizing that vitamin D can be a potential risk factor for development of coronary artery disease
Assessment of vitamin D status and its association with insulin resistance among type 2 diabetic subjects
Background: The 21st century has seen the rise of diabetes mellitus as one of the major metabolic issues as is vitamin D deficiency which has been found to be pandemic worldwide. The present study is an endeavor to study the status of serum vitamin D levels in relation to the glycemic and insulin resistance status in type 2 diabetes mellitus patients.Methods: The present is a cross-sectional study with a sample size of 100 type 2 diabetic subjects in the age group of 30-60 years. Serum vitamin D and Insulin levels were estimated using the ELISA technique. HbA1c levels were measured using immunoturbidimetric assays and plasma glucose levels were determined using glucose oxidase- peroxidase method.Results: The fasting plasma glucose, HbA1c and serum insulin levels were found to be significantly higher in those with vitamin D levels below the normal cut-off value of less than 30ng/ml (p value <0.01). Also, the insulin resistance calculated using HOMA-IR was found to be higher in those subjects having vitamin D deficiency or insufficiency.Conclusions: Hence, the study suggests that vitamin D deficiency contributes to further insulin resistance and poorer long-term diabetic control in type 2 diabetes mellitus subjects
Gestational diabetes mellitus, Vitamin D status and fetomaternal outcome
Background: Diabetes is the most common medical complication of pregnancy. Vitamin D deficiency which was initially considered only to influence bone metabolism, is now known to exert a wide spectrum of extra-skeletal effects. Vitamin D deficiency is closely associated with gestational diabetes mellitus, it also leads to adverse maternal and child outcome. Objective of this study was to compare the vitamin D levels in healthy pregnant women and women with gestational diabetes mellitus and to observe the feto-maternal outcome.Methods: This prospective study was carried out on 160 pregnant women between the age group 20-40 years attending the Obstetrics and Gynaecology department of JNMC, AMU, Aligarh from October 2016 to October 2018. Women were divided into group A- normal pregnant women and group B- women with GDM. Estimation of vitamin D was done in both the groups.Results: Mean vitamin D levels were lower in women with GDM as compared to normal pregnant women.Conclusions: Women with vitamin D deficiency have an increased risk of developing GDM and adverse feto maternal outcome as compared to those who had normal level of vitamin
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