A comparison of reimbursement recommendations by European HTA agencies : Is there opportunity for further alignment?

Introduction: In Europe and beyond, the rising costs of healthcare and limited healthcare resources have resulted in the implementation of health technology assessment (HTA) to inform health policy and reimbursement decision-making. European legislation has provided a harmonized route for the regulatory process with the European Medicines Agency, but reimbursement decision-making still remains the responsibility of each country. There is a recognized need to move toward a more objective and collaborative reimbursement environment for new medicines in Europe. Therefore, the aim of this study was to objectively assess and compare the national reimbursement recommendations of 9 European jurisdictions following European Medicines Agency (EMA) recommendation for centralized marketing authorization. Methods: Using publicly available data and newly developed classification tools, this study appraised 9 European reimbursement systems by assessing HTA processes and the relationship between the regulatory, HTA and decision-making organizations. Each national HTA agency was classified according to two novel taxonomies. The System taxonomy, focuses on the position of the HTA agency within the national reimbursement system according to the relationship between the regulator, the HTA-performing agency, and the reimbursement decision-making coverage body. The HTA Process taxonomy distinguishes between the individual HTA agency's approach to economic and therapeutic evaluation and the inclusion of an independent appraisal step. The taxonomic groups were subsequently compared with national HTA recommendations. Results: This study identified European national reimbursement recommendations for 102 new active substances (NASs) approved by the EMA from 2008 to 2012. These reimbursement recommendations were compared using a novel classification tool and identified alignment between the organizational structure of reimbursement systems (System taxonomy) and HTA recommendations. However, there was less alignment between the HTA processes and recommendations. Conclusions: In order to move forward to a more harmonized HTA environment within Europe, it is first necessary to understand the variation in HTA practices within Europe. This study has identified alignment between HTA recommendations and the System taxonomy and one of the major implications of this study is that such alignment could support a more collaborative HTA environment in Europe.Peer reviewedFinal Published versio

ALTERNATIVE METHODS OF FORECASTING AGRICULTURAL WATER DEMAND: A CASE STUDY ON THE FLINT RIVER BASIN IN GEORGIA

Future agricultural water demands are determined by employing forecasts from irrigated crop acreage models. Forecasts of prices and yields, and variances and covariances of crop returns are employed for forecasting crop acreage. Results provide insights into the value of rational expectations in forecasting agricultural water demand.Resource /Energy Economics and Policy,

The media equation and team formation: Further evidence for experience as a moderator

This study extends previous media equation research, which showed that interdependence but not identity leads to team affiliation effects with computers. The current study used an identity manipulation that more closely replicated the manipulation used in traditional team and group formation research than the original media equation research in this area. The study also sought further evidence for the relationship between experience with computers and behaviour reflecting a media equation pattern of results. Sixty students from the University of Queensland voluntarily participated in the study. Participants were assigned to one of three conditions: control, human team (a team made of only humans) or human-computer team (a team made of computers and humans). Questionnaire measures assessing participants’ affective experience, attitudes and opinions were taken. Participants of high experience, but not low experience, when assigned to either of the team conditions enjoyed the tasks completed on the computer more than participants who worked on their own. When assigned to a team that involved a computer, participants of high experience, but not low experience, reacted negatively towards the computer (in comparison to high experience participants working on their own or on a team without a computer as a team member) – rating the information provided by the computer lower, rating themselves as less influenced by the computer and changing their own ratings and rankings to be less like those of the computer. These results are interpreted in light of the ‘Black Sheep’ literature and recognized as a media equation pattern of results

Effects of Team-Based Computer Interaction: The Media Equation and Game Design Considerations

The current paper applies media equation research to video game de-sign. The paper presents a review of the existing media equation research, de-scribes a specific study conducted by the authors, discusses how the findings of the study can be used to inform future game design, and explores how other media equation findings might be incorporated into game design. The specific study, discussed in detail in the paper, explores the notion of team formation between humans and computer team-mates. The results show that while highly experienced users will accept a computer as a team-mate, they tend to react more negatively towards the computer than to human teammates (a ‘Black Sheep’ Effect

the Growth Potential for the Indiana Livestock Industries

Feed, processing capacity, population density versus animal density, and environmental capacities are the four different dimensions of livestock location and growth potential analyzed for Indiana. These four dimensions provide livestock producers, government officials, and livestock associations a valuable perspective on the constraints that could limit Indiana’s livestock growth potential. Comparisons among 21 states on these dimensions indicated that Indiana is a second choice of states for livestock growth; Kansas and Iowa are the only first choices. Indiana’s strength in the state comparison is its ability to assimilate the phosphorus produced by livestock and commercial phosphorus. As environmental regulations continue to tighten and shift from nitrogen to phosphorus based application standards for manure, the ability to assimilate phosphorus will continue to be one of Indiana’s strengths, along with its abundance of feed and swine processing capacity. Population density is the key dimension that is a disadvantage for Indiana. Within the state of Indiana, the West Central district has key advantages compared to other districts of the state. This district has an abundance of feed, the second lowest population density in the state, and excess phosphorus assimilation capacity. This district does not have processing capacity for any species, but the adjoining districts do have adequate processing capacity. Overall, the results show that Indiana has the potential to grow the livestock sector. However, there will be constraints such as population density that require more in-depth study to determine how to address this potential limitation on growth.Livestock Growth, Animal Waste, Feed Capacity, Livestock Processing Capacity, Animal Density, Population Density

Economic Impact of the Conservation Reserve Program in North Dakota

Environmental Economics and Policy, Land Economics/Use,

Arkansas Landlord Selection of Land-Leasing Contract Type and Terms

Land leasing is a major source of the land input to production agriculture. Responses from a survey of landlords leasing crop land in Arkansas are analyzed to better understand those factors motivating landlords in the type of lease they select and the terms of those leases. Probit models are estimated to determine the relative importance of variables representing credit constraint, agency problem, and risk aversion factors. Regression models then estimate the impact of site, landlord, and tenant characteristics on contract terms – the percentage of crop and cost sharing arrangements between landlord and tenant. Probit results suggest credit constraint factors influence lease-type selection. Risk aversion, managerial ability, and social capital factors are also supported. Regression models show that land and crop characteristics are significant determinants of contract terms.Land leasing, Probit, Contract, Production agriculture, Land Economics/Use,

Raven’s Work in Tlingit Ethno-geography

Chapter in the publication: Holton, Gary and Thomas F.Thornton. (Eds.) Language and Toponymy in Alaska and Beyond: Papers in Honor of James Kari. Language Documentation & Conservation Special Publication no. 17. Honolulu: University of Hawai‘i Press.Ye

CONTRACT CHOICE SELECTION WITH LAND-LEASING AGREEMENTS

This study tests cropland contract hypotheses utilizing a landlord data set. Ordered probit and classical regression models are estimated and presented identifying factors that affect the contract type selection and terms. Results suggest credit constraints are a viable land-leasing hypothesis. Risk aversion, managerial ability, and social capital are also supported.Land Economics/Use,