Leveraging Node Attributes for Incomplete Relational Data

Relational data are usually highly incomplete in practice, which inspires us to leverage side information to improve the performance of community detection and link prediction. This paper presents a Bayesian probabilistic approach that incorporates various kinds of node attributes encoded in binary form in relational models with Poisson likelihood. Our method works flexibly with both directed and undirected relational networks. The inference can be done by efficient Gibbs sampling which leverages sparsity of both networks and node attributes. Extensive experiments show that our models achieve the state-of-the-art link prediction results, especially with highly incomplete relational data.Comment: Appearing in ICML 201

Non-Invasive Mitochondrial Modulation With Near-Infrared Light Reduces Brain Injury After Stroke

Acute ischemic stroke is a debilitating disease that causes significant brain injury. While rapid restoration of blood flow is critical to salvage the ischemic brain, reperfusion of tissue can further drive brain damage by inducing generation of mitochondrial reactive oxygen species (Chouchani et al., 2014a). Recent studies by our group found that noninvasive mitochondrial modulation (NIMM) with near-infrared (NIR) light can limit the production of reactive oxygen species following global brain ischemia (T. H. Sanderson et al., 2018). NIR interacts with the rate limiting step of the mitochondrial electron transport chain (ETC), cytochrome c oxidase (COX), and modulates mitochondrial respiration. Under conditions of mitochondrial stress, such as reperfusion following ischemia, specific wavelengths of NIR can limit the production of ROS by transiently reducing COX activity, and thus limiting a critical force for ROS production, stress-induced mitochondrial membrane potential hyperpolarization. Here, we evaluated a specific combination of COX-inhibitory NIR (750nm and 950nm) as a potential therapy for acute ischemic stroke using a rat MCAO model. We found the NIMM at the onset of reperfusion resulted in a 20% reduction of infarct volume measured 24 hours post reperfusion. This reduction in infarct was sustained through the chronic phase of stroke and the neuroprotective benefit increased to 50% infarct reduction when treatment duration was douple to 240 minutes. Our data suggest that NIMM by targeting COX with NIR irradiation at the onset of reperfusion can be a beneficial therapy to minimize reperfusion injury following acute ischemic stroke and that extending the treatment window beyond the initial ROS burst can target other long-term causes of neuronal death following stroke such as inflammation

Ferromagnetic models for cooperative behavior: Revisiting Universality in complex phenomena

Ferromagnetic models are harmonic oscillators in statistical mechanics. Beyond their original scope in tackling phase transition and symmetry breaking in theoretical physics, they are nowadays experiencing a renewal applicative interest as they capture the main features of disparate complex phenomena, whose quantitative investigation in the past were forbidden due to data lacking. After a streamlined introduction to these models, suitably embedded on random graphs, aim of the present paper is to show their importance in a plethora of widespread research fields, so to highlight the unifying framework reached by using statistical mechanics as a tool for their investigation. Specifically we will deal with examples stemmed from sociology, chemistry, cybernetics (electronics) and biology (immunology).Comment: Contributing to the proceedings of the Conference "Mathematical models and methods for Planet Heart", INdAM, Rome 201

A finite element stress analysis of spur gears including fillet radii and rim thickness effects

Spur gear stress analysis results are presented for a variety of loading conditions, support conditions, fillet radii, and rim thickness. These results are obtained using the SAP IV finite-element code. The maximum stresses, occurring at the root surface, substantially increase with decreasing rim thickness for partially supported rims (that is, with loose-fitting hubs). For fully supported rims (that is, with tight-fitting hubs), the root surface stresses slightly decrease with decreasing rim thickness. The fillet radius is found to have a significant effect upon the maximum stresses at the root surface. These stresses increase with increasing fillet radius. The fillet radius has little effect upon the internal root section stresses

Modeling Acidification Recovery on Threatened Ecosystems: Application to the Evaluation of the Gothenburg Protocol in France

To evaluate the acid deposition reduction negotiated for 2010 within the UNECE LRTAP Gothenburg Protocol, sulphur and nitrogen deposition time-series (1880–2100) were compared to critical loads of acidity on five French ecosystems: Massif Central basalt (site 1) and granite (2); Paris Bassin tertiary sands (3); Vosges mountains sandstone (4) and Landes eolian sands (5). The SAFE model was used to estimate the response of soil solution pH and [A1] [BC] ratio to the deposition scenario. Among the five sites, critical loads were exceeded in the past at sites 3, 4 and 5. Sites 3 and 4 were still expected to exceed in 2010, the Protocol year. Further reduction of atmospheric deposition, mainly nitrogen, would be needed to achieve recovery on these ecosystems. At sites 3, 4 and 5, the delay between the critical load exceedance and the violation of the critical chemical criterion was estimated to be 10 to 30 years in the top soil and 50 to 90 years in the deeper soil. At site 5, a recovery was expected in the top soil in 2010 with a time lag of 10 years. Unexpectedly, soil pH continued to decrease after 1980 in the deeper soil at sites 2 and 5. This time lag indicated that acidification moved down the soil profile as a consequence of slow base cation depletion by ion exchange. This delayed response of the soil solution was the result of the combination of weathering rates and vegetation uptake but also of the relative ratio between base cation deposition and acid compounds

Cavity-assisted manipulation of freely rotating silicon nanorods in high vacuum

Optical control of nanoscale objects has recently developed into a thriving field of research with far-reaching promises for precision measurements, fundamental quantum physics and studies on single-particle thermodynamics. Here, we demonstrate the optical manipulation of silicon nanorods in high vacuum. Initially, we sculpture these particles into a silicon substrate with a tailored geometry to facilitate their launch into high vacuum by laser-induced mechanical cleavage. We manipulate and trace their center-of-mass and rotational motion through the interaction with an intense intra-cavity field. Our experiments show optical forces on nanorotors three times stronger than on silicon nanospheres of the same mass. The optical torque experienced by the spinning rods will enable cooling of the rotational motion and torsional opto-mechanics in a dissipation-free environment.Comment: 8 page