Gastroprotective effect and in vitro Antioxidant Activities of the Aqueous Extract from Artemisia absinthium L Aerial Parts

Artemisia absinthium L. is a medicinal plant largely used in traditional medicine. The aim of this study was to estimate the content of polyphenols, and flavonoids compounds and also to evaluate the antioxidant and the anti-ulcer activities of the Aqueous extract from Artemisia absinthium L. aerial parts. The Folin-Ciocalteau and AlCl3 methods were applied in order to quantify the polyphenolic and flavonoids contents, respectively. However, DPPH   method was used to evaluate the in vitro antioxidant activity. Quantitative analysis of the yield and phenolic content of the aqueous extract of Artemisia absinthium showed that the yield of the aqueous extract was 19.32% and its phenolic content was 58.66 ± 2.16 μg GAE / mg dry extract for polyphenols and 6.85 μg QE / mg dry extract for the flavonoids. The antioxidant activity of the plant extract evaluated by the DPPH test is very important (IC50=45.48±0.37 µg/ml). Treatment of mice with the aqueous extract of Artemisia absinthium at a dose of 400 mg / kg significantly reduced the ulcerogenic effect of ethanol on the gastric wall with an estimated protection rate of 91%. These findings suggest that Artemisia absinthium L.  aqueous extract possessed good antiulcer and antioxidant potentials. This supports the traditional claims of this plant in folklore medicine. Keywords: Artemisia absinthium, polyphenols, antioxidant activity, gastric ulcer, ethanol

Artemisia absinthium L.: Aplicabilidade na saúde humana / Artemisia absinthium L.: Applicability in human health

Desde a antiguidade as plantas com propriedades medicinais são utilizadas como recurso terapêutico para a sobrevivência, além de servirem de matéria-prima para a fabricação de produtos, medicamentos fitoterápicos e para a criação de novos compostos farmacológicos ativos. A Artemisia absinthium L. popularmente conhecida como Losna é uma planta aromática e medicinal de etnofarmacológico interesse, que vem sendo amplamente utilizada de forma empírica no tratamento de diversas doenças. Nesse contexto, definiu-se como objetivo realizar um levantamento bibliográfico investigando a aplicabilidade da Artemisia absinthium L. na saúde humana e verificar a sua composição química. A partir da revisão de literatura foram selecionadas 26 publicações, escritas no idioma português e inglês, constadas entre os anos de 2011 a 2020. Os resultados demonstram que a planta detém de uma rica composição química responsável por diversas ações no organismo, dentre eles os monoterpenos, sesquiterpenos, flavonóides, polifenóis, taninos, macro-micro elementos e aminoácidos. Seus constituintes variam de acordo com parte da planta utilizada e a região de cultivo. Possui ampla aplicabilidade na saúde, pois apresenta atividade imunomoduladora, antioxidante, antiparasitária, anti-helmíntica, anticancerígena, citotóxica, antimicrobiana, antifúngica, hepatoprotetora, antiinflamatória e hipoglicemiante, podendo servir de base para o desenvolvimento de novas estratégias terapêuticas

Multifunctional Hydroxyapatite Coated with Arthemisia absinthium Composites

There is significant research showing that essential oils extracted from the plants have antibacterial effects. The purpose of this study was to develop a biocomposite based on hydroxyapatite coated with Artemisia absinthium essential oil and to highlight its antibacterial activity. Therefore, present studies are aimed at developing new materials combining hydroxyapatite with Artemisia absinthium essential oil, in order to avoid postoperative infections. The purpose of this work is to highlight the antimicrobial properties of the Artemisia absinthium essential oil-hydroxyapatite composites obtained by a simple method and at low costs. The structural properties and antimicrobial efficiency of the Artemisia absinthium essential oil-hydroxyapatite composite have been studied. The samples based on Artemisia absinthium essential oil analyzed in this study showed that wormwood essential oil presented the highest efficacy against the fungal strain of C. parapsilosis. It has been shown that wormwood essential oil has a strong antimicrobial effect against the microbial strains tested in this study. Furthermore, the antimicrobial properties of the biocomposites based on hydroxyapatite and essential oil are due to the presence of the essential oil in the samples.</jats:p

Multifunctional Hydroxyapatite Coated with Arthemisia absinthium Composites

There is significant research showing that essential oils extracted from the plants have antibacterial effects. The purpose of this study was to develop a biocomposite based on hydroxyapatite coated with Artemisia absinthium essential oil and to highlight its antibacterial activity. Therefore, present studies are aimed at developing new materials combining hydroxyapatite with Artemisia absinthium essential oil, in order to avoid postoperative infections. The purpose of this work is to highlight the antimicrobial properties of the Artemisia absinthium essential oil-hydroxyapatite composites obtained by a simple method and at low costs. The structural properties and antimicrobial efficiency of the Artemisia absinthium essential oil-hydroxyapatite composite have been studied. The samples based on Artemisia absinthium essential oil analyzed in this study showed that wormwood essential oil presented the highest efficacy against the fungal strain of C. parapsilosis. It has been shown that wormwood essential oil has a strong antimicrobial effect against the microbial strains tested in this study. Furthermore, the antimicrobial properties of the biocomposites based on hydroxyapatite and essential oil are due to the presence of the essential oil in the samples