Progress in the Application of Molecular Biology Testing Techniques in Medical Testing

Molecular biology testing technology is an important means of medical testing. Since 2003, this technology has entered various fields of medical testing and has been widely and frequently applied, bringing new support to medical testing. Relying on the advantages of high sensitivity, low misjudgment rate, and high specificity of molecular biology testing technology, the efficiency of medical testing has been greatly improved, and it has become an irreplaceable presence in medical testing. The article focuses on the main technologies in molecular biology testing and provides a detailed discussion on the application of some technologies in medical testing

Spicy science: David Julius and the discovery of temperature-sensitive TRP channels.

This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the University of California, San Francisco Medical School. He is a member of the National Academy of Sciences and has received many distinguished awards for his landmark discoveries of the molecular basis of pain and thermosensation

The Problem with Academic Medicine: Engineering Our Way into and out of the Mess

Medical schools have come to resemble schools of molecular biology, while medical research has become focused on molecules rather than patient

The nucleic acid revolution continues - will forensic biology become forensic molecular biology?

Molecular biology has evolved far beyond that which could have been predicted at the time DNA identity testing was established. Indeed we should now perhaps be referring to "forensic molecular biology." Aside from DNA's established role in identifying the "who" in crime investigations, other developments in medical and developmental molecular biology are now ripe for application to forensic challenges. The impact of DNA methylation and other post-fertilization DNA modifications, plus the emerging role of small RNAs in the control of gene expression, is re-writing our understanding of human biology. It is apparent that these emerging technologies will expand forensic molecular biology to allow for inferences about "when" a crime took place and "what" took place. However, just as the introduction of DNA identity testing engendered many challenges, so the expansion of molecular biology into these domains will raise again the issues of scientific validity, interpretation, probative value, and infringement of personal liberties. This Commentary ponders some of these emerging issues, and presents some ideas on how they will affect the conduct of forensic molecular biology in the foreseeable future

Pengembangan Model E–Learning: Integrasi Video Materi Presentasi dan Google Classroom untuk Mata Kuliah Biologi Molekuler

Molecular Biology is one of compulsory courses in Medical Laboratory Technology Department. This course related with central dogma of molecular biology, such as material genetic and its expression to the protein. Student had the most difficulties learning molecular biology, since interpretation of topic is rarely difficult to understood. Furthermore, the COVID–19 pandemic situation is influencing the effective teaching at this course. This study was conducted to explore student’s evaluation on the molecular biology course using E–learning tools. We produced presentation on video and interactive discussion using Google Classroom. The study involved 119 students of grade sixth semester in Medical Technology Department, Universitas Nahdlatul Ulama Surabaya–Indonesia. The data were collected through questionnaire and interviews using Google Form and Zoom meeting. Result of the study indicated that 61.3% student were chosen to use the integration of video presentation and Google Classroom than Zoom meeting only. Using the method, as much as 58% the student can understand the course around 50–60%. These free–access tools are easily used by student to study and discuss the course. This study has shown that the integration of such multimedia tools, namely video presentation and Google Classroom contributes to an innovative approach in molecular biology teaching

Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo

This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030000) and the CAS-Novonordisk Foundation, as well as grants from the ‘1000 talents’ recruitment program, and a ‘Great-wall professorship’ from the CAS-Novonordisk Foundation all to JRS. We are grateful to all the members of Molecular Energetics Group for their support and discussion of the results. We would like to thank the Center for Biological Imaging from Institute of Biophysics Chinese Academy of Sciences and Professor Zhaohui Wang's Lab from Institute of Genetics and Developmental Biology Chinese Academy of Sciences for confocal microscopy and the Center for Developmental Biology from Institute of Genetics and Developmental Biology Chinese Academy of Sciences and Dr. Jai from Core Facility for Protein Research from Institute of Biophysics Chinese Academy of Sciences for flow cytometry. We are grateful to Dr. Kuang from Purdue University and Dr. Zhu from Chinese Academy of Medical Sciences Peking Union Medical College for the kind donation of Myf5-Cre mice and Dr. Wolfrum from the Institute of Food Nutrition and Health at the ETH Zurich for the kind donation of the Ucp1-DTR mice. Xun Huang provided valuable comments on previous versions of the manuscript.Peer reviewedPublisher PD

The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease

This study was supported by Parkinson’s Disease Foundation (IRGP 09-11 (P.T.)), the Royal Society (2006/R1 (P.T.)), the Wellcome Trust (WT080782MF (P.T.)), the Biotechnology and Biological Sciences Research Council (P.T. and H.L.M.), the National Institutes of Health (DK057978) (R.M.E.), and by grants from the Leona M. and Harry B. Helmsley Charitable Trust (R.M.E.), the Glenn Foundation for Medical Research (R.M.E.), and the Ellison Medical Foundation (R.M.E.). R.M.E. is an investigator at the Howard Hughes Medical Institute and March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute. The authors would like to thank Lynne J. Hocking, University of Aberdeen, for her assistance with the statistics. We are grateful to the staff of the Medical Research Facility for their help with the animal care and the microscopy core facility at the University of Aberdeen for the use of microscopy equipment.Peer reviewedPublisher PD

Summer 2017 GSBMS Alumni Connections

New York Medical College Marks its 158th Commencement Ceremony, Bestowing Degrees on 395 Graduates New York Medical College and the Westchester Medical Center Health Network Host Ceremonial Signing of Academic Affiliation Agreement Touro College Set to Launch Nursing Program at New York Medical College Department of Biochemistry and Molecular Biology Hosts Fulbright Scholar to Study Effect of Neuropeptides on Stress Disorders Lectureship Honors the Late Gabor Kaley, Ph.D. Graduate Student Research Forum Showcases Impressive Scientific Work Department of Cell Biology and Anatomy Hosts Annual Research Forumhttps://touroscholar.touro.edu/nymc_gsbms_book/1012/thumbnail.jp

Big Data Transforms Discovery-Utilization Therapeutics Continuum.

Enabling omic technologies adopt a holistic view to produce unprecedented insights into the molecular underpinnings of health and disease, in part, by generating massive high-dimensional biological data. Leveraging these systems-level insights as an engine driving the healthcare evolution is maximized through integration with medical, demographic, and environmental datasets from individuals to populations. Big data analytics has accordingly emerged to add value to the technical aspects of storage, transfer, and analysis required for merging vast arrays of omic-, clinical-, and eco-datasets. In turn, this new field at the interface of biology, medicine, and information science is systematically transforming modern therapeutics across discovery, development, regulation, and utilization