Book Reviews

Social Chaucer (Paul Strohm) (Reviewed by R. James Goldstein, The John Hopkins University)Wordsworth: The Sense of History (Alan Liu) (Reviewed by William Galperin, Rutgers University, New Brunswick)Soundings in Critical Theory (Dominick LaCapra) (Reviewed by Lloyd S. Kramer, University of North Carolina, Chapel Hill)Professing Literature (Gerald Graff) (Reviewed by John Brereton, Univ. of Massachusetts, Boston

Book Reviews

Spenserian Poetics: Idolatry, Iconoclasm, and Magic (Kenneth Gross) (Reviewed by Jonathan Goldberg, The John Hopkins University)The Social Vision of William Blake (Michael Ferber) (Reviewed by Karen Shabetai, University of Washington)The Industrial Reformation of English Fiction: Social Discourse and Narrative Form, 1832-1867 (Catherine Gallagher) (Reviewed by John Kucich, University of Michigan, Ann Arbor)Charlotte Brontë and Sexuality (John Maynard) (Reviewed by Martha Vicinus, University of Michigan)Henry James: The Writer and His Work (Tony Tanner) (Reviewed by George Bishop, Daemen College)Wallace Stevens: A Mythology of Self (Milton J. Bates) (Reviewed by John N. Serio, Clarkson University)Why Nietzsche Now? (Daniel O\u27Hara) (Reviewed by John McGowan, University of Rochester)Nietzsche: Life as Literature (Alexander Nehamas) (Reviewed by John McGowan, University of Rochester

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy

Chronic neurohormonal and mechanical stresses are central fea-tures of heart disease. Increasing evidence supports a role forthe transient receptor potential canonical channels TRPC3 andTRPC6 in this pathophysiology. Channel expression for both is nor-mally very low but is increased by cardiac disease, and geneticgain- or loss-of-function studies support contributions to hypertro-phy and dysfunction. Selective small-molecule inhibitors remainscarce, and none target both channels, which may be useful giventhe high homology among them and evidence of redundant sig-naling. Here we tested selective TRPC3/6 antagonists (GSK2332255Band GSK2833503A; IC50,3–21 nM against TRPC3 and TRPC6) andfound dose-dependent blockade of cell hypertrophy signaling trig-gered by angiotensin II or endothelin-1 in HEK293T cells as well as inneonatal and adult cardiac myocytes. In vivo efficacy in mice andrats was greatly limited by rapid metabolism and high protein bind-ing, although antifibrotic effects with pressure overload were ob-served. Intriguingly, although gene deletion of TRPC3 or TRPC6alone did not protect against hypertrophy or dysfunction frompressure overload, combined deletion was protective, support-ing the value of dual inhibition. Further development of thispharmaceutical class may yield a useful therapeutic agent forheart disease management.Fil: Seo, Kinya. Johns Hopkins Medical Institutions. Department of Medicine; Estados UnidosFil: Rainer, Peter P.. Johns Hopkins Medical Institutions. Department of Medicine; Estados Unidos. Medical University of Graz. Department of Medicine; AustriaFil: Shalkey Hahn, Virginia. Johns Hopkins Medical Institutions. Department of Medicine; Estados UnidosFil: Lee, Dong-ik. Johns Hopkins Medical Institutions. Department of Medicine; Estados UnidosFil: Jo, Su-Hyun. Kangwon National University School of Medicine; Corea del Sur. Johns Hopkins Medical Institutions. Department of Medicine; Estados UnidosFil: Andersen, Asger. Aarhus University Hospital. Department of Cardiology; DinamarcaFil: Liu, Ting. Johns Hopkins Medical Institutions. Department of Medicine; Estados UnidosFil: Xu, Xiaoping. GlaxoSmithKline Heart Failure Discovery Performance Unit; Estados UnidosFil: Willette, Robert N.. GlaxoSmithKline Heart Failure Discovery Performance Unit; Estados UnidosFil: Lepore, John J.. GlaxoSmithKline Heart Failure Discovery Performance Unit; Estados UnidosFil: Marino, Joseph P.. GlaxoSmithKline Heart Failure Discovery Performance Unit; Estados UnidosFil: Birnbaumer, Lutz. ational Institute of Environmental Health Sciences; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Schnackenberg, Christine G.. GlaxoSmithKline Heart Failure Discovery Performance Unit; Estados UnidosFil: Kass, David A.. Johns Hopkins Medical Institutions. Department of Medicine; Estados Unido

Book Reviews

The Gaping Pig: Literature and Metamorphosis (Irving Massey) (Reviewed by Charles Baxter, Wayne State University)Process of Speech: Puritan Religious Writing and Paradise Lost (Boyd M. Berry) (Reviewed by William E. Cain, The John Hopkins University)The Novels of Theodore Dreiser (Donald Pizer) (Reviewed by Linda W. Wagner, Michigan State University)A Glossary of Faulkner\u27s South (Calvin S. Brown) (Reviewed by Linda W. Wagner, Michigan State University)Marlowe, Tamburlaine, and Magic (James Robinson Howe) (Reviewed by Wayne Shumaker, University of California, Berkeley)Folklore and Fakelore: Essays Toward a Discipline of Folk Studies (Richard M. Dorson) (Reviewed by Michael J. Bell, Wayne State University)Lucan: An Introduction (Frederick M. Ahl) (Reviewed by John F. Makowski, Loyola University of Chicago)Hawthorne, Melville, and the Novel (Richard H. Brodhead) (Reviewed by John Bassett, Wayne State University)The Illustrator and the Book in England from 1790 to 1914 (Gordon N. Ray) (Reviewed by John R. Reed, )The Romantic Will (Michael G. Cooke) (Reviewed by John R. Reed,

Book Reviews

Literary Landscape: Turner and Constable (Ronald Paulson) (Reviewed by Karl Kroeber, Columbia University)Milton and the Science of the Saints (Georgia B. Christopher) (Reviewed by Boyd Berry, Virginia Commonwealth University)Henry Vaughan: The Unfolding Vision (Jonathan F. S. Post) (Reviewed by Boyd Berry, Virginia Commonwealth University)Dickens and the Short Story (Deborah A. Thomas) (Reviewed by John R. Reed, Wayne State University)Prodigals and Pilgrims: The American Revolution Against Patriarchal Authority, 1750-1800 (Jay Fliegelman) (Reviewed by Jonathan Auerbach, The John Hopkins University)Roland Barthes: Structuralism and After (Annette Lavers) (Reviewed by Betty R. McGraw, Kansas State University

Interview with John Roger Stemen, June 26, 2001

John Roger Stemen was interviewed on June 26, 2001 by Michael J. Birkner about his experiences before he became a professor of History at Gettysburg College. He discusses his childhood in Indiana and focuses on his undergraduate education at Yale University and his service in the photolithography unit in Korea. After the war he attended Indiana University and Johns Hopkins University, where he obtained his doctorate. Collection Note: This oral history was selected from the Oral History Collection maintained by Special Collections & College Archives. Transcripts are available for browsing in the Special Collections Reading Room, 4th floor, Musselman Library. GettDigital contains the complete listing of oral histories done from 1978 to the present. To view this list and to access selected digital versions please visit -- http://gettysburg.cdmhost.com/cdm/landingpage/collection/p16274coll

Norman N. Holland. UNITY IDENTITY TEXT SELF

без анотації Перекладено за виданням: Norman N. Holland. UNITY IDENTITY TEXT SELF // Reader-response criticism: From Formalism to Post-Structuralism / Ed. Jane P. Tompkins. – Baltimore: John Hopkins University Press, 1980. – 275 p. – pp. 118-133

Book Reviews

Tradition Counter Tradition: Love and the Form of Fiction (Joseph Allen Boone) (Reviewed by Linda Kauffman, University of North Carolina, Chapel Hill)Nostalgia and Sexual Difference: The Resistance to Contemporary Feminism (Janice Doane and Devon Hodges) (Reviewed by Sally Shuttleworth, University of Leeds)Patte,. s of Intention: On the Historical Explanation of Pictures (Michael Baxandall) (Reviewed by Ann Bermingham, University of California, Irvine)Theatrical Legitimation: Allegories of Genius in Seventeenth-Century England and France (Timothy Murray) (Reviewed by Jonathan Goldberg, The John Hopkins University)Reconstructing Individualism. Autonomy, Individuality, and the Self in Western Thought (Thomas C. Heller, Morton Sansa, and David E. Wellbery) (Reviewed by John Jay Baker, University of Tulsa)Poetic Form and British Romanticism (Stuart Curran) (Reviewed by Paul H. Fry, Yale University)Fictional Worlds (Thomas G. Pavel) (Reviewed by Michael Cornis-Pop, Harvard Center for Literary Studies)Cinema 1: The Movement-Image (Gilles Deleuze) (Reviewed by George Wilson, The John Hopkins University)Decomposing Figures: Rhetorical Readings in the Romantic Tradition (Cynthia Chase) (Reviewed by Jonathan Baldo, Eastman School of Music)The Tain Of The Mirror: Derrida And The Philosophy Of Reflection (Rodolphe Gasché) (Reviewed by Henry Staten, University of Utah)Literature and History: Theoretical Problems and Russian Case Studies (Gary Saul Morson) (Reviewed by Thomas D. Cohen, New School for Social Research

Book Reviews

American Poets from the Puritans to the Present (Hyatt H. Waggoner) (Reviewed by Daniel Hoffman, University of Pennsylvania)Gerard Manley Hopkins: The Poet as Victorian (Wendell Stacy Johnson) (Reviewed by John Pick, Marquette University)Tragedy and Melodrama: Versions of Experience (Robert Bechtold Heilman) (Reviewed by Irving Ribner, State University of New York at Stony Brook)The Lonely Labyrinth: Kierkegaard\u27s Pseudonymous Works (Josiah Thompson) (Reviewed by Louis H. Mackey, The University of Texas at Austin