Smooth Horizonless Geometries Deep Inside the Black-Hole Regime

This Letter has been highlighted by the editors as an Editor's Suggestion.This Letter has been highlighted by the editors as an Editor's Suggestion

Introductory Information and Editor\u27s Preface

Information about the publication, such as the Editorial Advisory Board and the Editorial Policy, and the Editor\u27s Preface for the issue

The Passion of the Infant Christ: Critical Edition

Although forgotten until quite recently, Caryll Houselander, who died in 1954, was a sensitive and profound English Roman Catholic writer on Christian spirituality. In this critical edition of her 1949 book The Passion of the Infant Christ, Houselander argues that the physical world is an inscaped revelation of the mind of the Creator. Every concrete object and every temporal event mirrors the eternal, just as the circumstances surrounding the birth of Jesus mirror the circumstances surrounding his death and resurrection. Editor Kerry Walters discusses both Houselander\u27s life and the primary themes of The Passion of the Infant Christ in his introduction to this critical edition of one of Houselander\u27s most insightful books.https://cupola.gettysburg.edu/books/1117/thumbnail.jp

Studying with Bream

Editor's note: letter to the Vórtex dossier in honor of Julian Bream

Julian Bream

Editor's note: letter to the Vórtex dossier in honor of Julian Bream

Julian Bream

Editor's note: letter to the Vórtex dossier in honor of Julian Bream

Studying with Bream

Editor's note: letter to the Vórtex dossier in honor of Julian Bream

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos.

The regulation of transcription requires the coordination of numerous activities on DNA, yet how transcription factors mediate these activities remains poorly understood. Here, we use lattice light-sheet microscopy to integrate single-molecule and high-speed 4D imaging in developing Drosophila embryos to study the nuclear organization and interactions of the key transcription factors Zelda and Bicoid. In contrast to previous studies suggesting stable, cooperative binding, we show that both factors interact with DNA with surprisingly high off-rates. We find that both factors form dynamic subnuclear hubs, and that Bicoid binding is enriched within Zelda hubs. Remarkably, these hubs are both short lived and interact only transiently with sites of active Bicoid-dependent transcription. Based on our observations, we hypothesize that, beyond simply forming bridges between DNA and the transcription machinery, transcription factors can organize other proteins into hubs that transiently drive multiple activities at their gene targets.Editorial noteThis article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter)

Volume 1, Number 1 - April 1977

The Free Press student newspaper was conceived and published in the Spring and Fall semesters of 1977 as an alternative news source to the Cowl. (Volume 1, Number 1 - April 28, 1977 - 4 pages in total.