648,352 research outputs found

    Digital Platforms and Antitrust Law

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    This Article is about “big data” and antitrust law. Big data, for my purposes, refers to digital platforms that enable the discovery and sharing of information by consumers, and the harvesting and analysis of consumer data by the platform. The obvious example of such a platform is Google. The big platforms owe their market dominance not to anticompetitive conduct but to economies of scale. This Article discusses three types of anticompetitive conduct associated with digital platforms: kill zone expropriation, acquisition of nascent rivals, and denial of access to data. There is nothing so unusual about digital platforms that would require a reform of the antitrust laws. Some are described as two-sided markets, but this designation, even after Ohio v. American Express Co., should not present an obstacle to the application of antitrust law. I. Introduction II. Platforms III. Competition Issues ... A. Kill Zone Expropriation ... B. Acquisition of Nascent Rivals ... C. Denial of Access to Data IV. Antitrust Law V. Conclusio

    A Survey of the Economic Role of Software Platforms in Computer-Based Industries

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    Software platforms are a critical component of the computer systems underpinning leading– edge products ranging from third– generation mobile phones to video games. After describing some key economic features of computer systems and software platforms, the paper presents case studies of personal computers, video games, personal digital assistants, smart mobile phones, and digital content devices. It then compares several economic aspects of these businesses including their industry evolution, pricing structures, and degrees of integration.software platforms, hardware platforms, network effects, bundling, multi-sided markets

    Theoretical Design and Analysis of Multivolume Digital Assays with Wide Dynamic Range Validated Experimentally with Microfluidic Digital PCR

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    This paper presents a protocol using theoretical methods and free software to design and analyze multivolume digital PCR (MV digital PCR) devices; the theory and software are also applicable to design and analysis of dilution series in digital PCR. MV digital PCR minimizes the total number of wells required for “digital” (single molecule) measurements while maintaining high dynamic range and high resolution. In some examples, multivolume designs with fewer than 200 total wells are predicted to provide dynamic range with 5-fold resolution similar to that of single-volume designs requiring 12 000 wells. Mathematical techniques were utilized and expanded to maximize the information obtained from each experiment and to quantify performance of devices and were experimentally validated using the SlipChip platform. MV digital PCR was demonstrated to perform reliably, and results from wells of different volumes agreed with one another. No artifacts due to different surface-to-volume ratios were observed, and single molecule amplification in volumes ranging from 1 to 125 nL was self-consistent. The device presented here was designed to meet the testing requirements for measuring clinically relevant levels of HIV viral load at the point-of-care (in plasma, 1 000 000 molecules/mL), and the predicted resolution and dynamic range was experimentally validated using a control sequence of DNA. This approach simplifies digital PCR experiments, saves space, and thus enables multiplexing using separate areas for each sample on one chip, and facilitates the development of new high-performance diagnostic tools for resource-limited applications. The theory and software presented here are general and are applicable to designing and analyzing other digital analytical platforms including digital immunoassays and digital bacterial analysis. It is not limited to SlipChip and could also be useful for the design of systems on platforms including valve-based and droplet-based platforms. In a separate publication by Shen et al. (J. Am. Chem. Soc., 2011, DOI: 10.1021/ja2060116), this approach is used to design and test digital RT-PCR devices for quantifying RNA

    The digital-only media consumer: Key findings from a conversation with all-digital millenials

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    This study offers insight on the digital-onlys, a sub-population of Millennials who only consume media through digital platforms. Based on informal group conversations with 16 to 34 year-olds, the study provides a snapshot of their daily media consumption and preliminary answers to why they regard digital content as the norm. These findings reveal that some consumers today are not simply abandoning traditional platforms and turning towards digital content, they actually seem to know no other way to consume media but on digital platforms. For them, the biggest consumption change would actually be to watch cable television, listen to FM radio or read a printed newspaper or magazine. Digital-onlys may represent a new kind of consumers that view their media habits as completely normal and organic. Indeed, some are not even aware they belong to this digital group. The participants shared common characteristics: an ability to adapt devices to their needs, an intrinsically digital lifestyle and a habit of bypassing traditional media to access a larger selection of content despite the fact they’re struggling with an overabundance of choice. Our conversations also revealed that digital-onlys are fully aware of the negative impact their media consumption habits can have on content creators, yet they cherish freedom above all else

    Digital PCR as a tool to measure HIV persistence

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    Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reservoir, one must be able to quantify the persisting virus. Traditionally, HIV persistence studies have used real-time PCR (qPCR) to measure the viral reservoir represented by HIV DNA and RNA. Most recently, digital PCR is gaining popularity as a novel approach to nucleic acid quantification as it allows for absolute target quantification. Various commercial digital PCR platforms are nowadays available that implement the principle of digital PCR, of which Bio-Rad's QX200 ddPCR is currently the most used platform in HIV research. Quantification of HIV by digital PCR is proving to be a valuable improvement over qPCR as it is argued to have a higher robustness to mismatches between the primers-probe set and heterogeneous HIV, and forfeits the need for a standard curve, both of which are known to complicate reliable quantification. However, currently available digital PCR platforms occasionally struggle with unexplained false-positive partitions, and reliable segregation between positive and negative droplets remains disputed. Future developments and advancements of the digital PCR technology are promising to aid in the accurate quantification and characterization of the persistent HIV reservoir

    Management of Digital Video Broadcasting Services in Open Delivery Platforms

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    The future of Digital Video Broadcasting (DVB) is moving towards solutions offering an efficient way of carrying interactive IP multimedia services over digital terrestrial broadcasting networks to handheld terminals. One of the most promising technologies is Digital Video Broadcasting-Handheld (DVB-H), at present under standardisation. Services deployed via this type of DVB technologies should enjoy reliability comparable to TV services and high quality standards. However, the market at present does not provide effective and economical solutions for the deployment of such services over multi-domain IP networks, due to their high level of unreliability. This paper focuses on service management, service level agreement (SLA) and network performance requirements of DVB-H services. Experimental results are presented concerning QoS sensitivity to network performance of DVB-H services delivered over a multi-domain IP network. Moreover, a solution for efficient and cost effective service management via QoS monitoring and control and network SLA design is proposed. The solution gives DVB-H operators the possibility of fully managing service QoS without being tied to third party operators

    Energy Power, Digital Infrastructure and Elearning Platforms: Afrrican Experience.

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    Information and communication technologies are one of the most pervasive technologies in the world, second only to 'human intelligence' or the human brain. Thus, understanding the factors that determine the diffusion of new technologies across african countries is important to understanding the process of economic development. And whereas, energy is linked with the capacity to perform, the rate at which energy is consumed for the acceleration of the pace of socio-economic activities is regarded as power. Consequently, it will be obvious that the magnitude of the standard of living in any society; the growth and development of such an economy; and its ability to affect the course of events(such as ICT revolution)will be a function of the extent to which its energy(power) resources are developed and utilised. This paper therefore argued for the need to provide assistance in reducing vulnerability and building the capacity of african countries to more widely reap the benefits of the clean development mechanism in areas such as the development of cleaner and renewable energies. Inevitably, this is the critical condition for the sustainability of the emergent e-learning platforms and digital networks in africa.ICT, learning, elearning, development, energy, power, information, communication, solar, electricity, wind, governance, africa, electronics, telecommunications, internet, digital, satellite, renewable energy, gas turbine, power plants, bandwidth, coal, hydro, biomass, steam, transmission, distribution, utilisation
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