The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus

The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes-related mortality. Among type 2 diabetes mellitus SNPs, rs1801282 is of particular interest because (i) it is harbored by peroxisome proliferator-activated receptor-γ2 (PPARγ2), which is the target for thiazolidinediones which are used as antidiabetic drugs, decreasing all-cause mortality in type 2 diabetes mellitus, and (ii) it is associated with insulin resistance and related traits, risk factors for overall mortality in type 2 diabetes mellitus. We investigated the role of PPARγ2 P12A, according to a dominant model (PA + AA vs. PP individuals) on incident all-cause mortality in three cohorts of type 2 diabetes mellitus, comprising a total of 1672 patients (462 deaths) and then performed a meta-analysis of ours and all available published data. In the three cohorts pooled and analyzed together, no association between PPARγ2 P12A and all-cause mortality was observed (HR 1.02, 95 % CI 0.79–1.33). Similar results were observed after adjusting for age, sex, smoking habits, and BMI (HR 1.09, 95 % CI 0.83–1.43). In a meta-analysis of ours and all studies previously published (n = 3241 individuals; 666 events), no association was observed between PPARγ2 P12A and all-cause mortality (HR 1.07, 95 % CI 0.85–1.33). Results from our individual samples as well as from our meta-analysis suggest that the PPARγ2 P12A does not significantly affect all-cause mortality in patients with type 2 diabetes mellitus

Facilitators and barriers of adaptation to diabetes: experiences of Iranian patients

Background: Diabetes mellitus is one of the most challenging and burdensome chronic diseases of the 21st century and More than 1% of the Iranian urban population older than 20 years develops Type 2 diabetes each year. Living with diabetes mellitus has been described as a dynamic personal transitional adaptation, based on restructuring of the illness perceived experience and management of the self. Adaptation to Type 2 Diabetes mellitus is an integral part of diabetes care.This study explored the experiences of facilitators and barriers adaptation to Type 2 Diabetes by Iranian patients.Methods: This study was conducted by using qualitative content analysis. Data were collected via in-depth, semi-structured and face to face interviews with 15 patients with type2 diabetes.Results: Three themes emerged from collected data, including a) individual context with Beliefs, personal background, and previous experience subthemes. b) supportive system with Family, Society and Health organizations subthemes and c) self-comparison with comparison with other diabetes and comparison with other diseases subthemes.Conclusions: Identifying and managing Facilitators and Barriers adaptation to Type 2 Diabetes mellitus are an integral part of diabetes care. This study provides a better understanding of the factors from perspective of patients and it can be utilized by health care providers to adapt their health care and education contents to better meet the needs of people with diabetes. © 2014 Karimi Moonaghi et al.; licensee BioMed Central Ltd

Perbedaan Kadar Asam Urat pada Penderita Hipertensi dengan Diabetes Melitus Tipe 2 dan tanpa Diabetes Melitus Tipe 2 di Rumah Sakit Umum Daerah Dr. Sayidiman Magetan

Background: The increasing levels of uric acid plays an important role in the morbidity of patients with hypertension. DM is a common comorbid hypertensive patients. Objective: To know the distinction of uric acid levels in hypertensive patients with type 2 diabetes mellitus and without diabetes mellitus type 2 in Dr. Sayidiman Hospitals Magetan. Methods: Researchers conducted an observational analytic research with cross sectional study design. Subjects were hypertensive patients with type 2 diabetes mellitus and without tipe 2 diabetes mellitus in Dr. Sayidiman Hospitals. The sampling technique performed in consecutive sampling. Data were obtained from medical records of patients from January 2012 to June 2015. Statistical analysis used independent T test. Results: This study used 54 sample, consists of 27 patients in the group of hypertension with type 2 diabetes mellitus and 27 patients in the group of hypertensive without type 2 diabetes mellitus. The difference between the mean levels of uric acid in hypertension with type 2 diabetes mellitus group 6.559 ± 2.2560 mg/dl compared with hypertension without type 2 diabetes mellitus group 4.922 ± 1.3051 mg/dl with p = 0.002. Conclusions: There was distinction of uric acid levels in hypertensive patients with type 2 diabetes mellitus and without type 2 diabetes mellitus

KONTEKSTUALISASI PROSES KEPERAWATAN DIABETES MELLITUS TIPE 2 BERBASIS NEEDS ANALYSIS

Although some previous studies have discussed the nursing process for type 2 diabetes mellitus; however, research that specifically discusses adapting the nursing process for type 2 diabetes mellitus through needs analysis has never been studied before. This systematic review aims to review some research publications on nurses' understanding of type 2 diabetes mellitus, the nursing process for patients with type 2 diabetes mellitus, and a needs analysis based type 2 nursing process training model. By using descriptive qualitative research methods, this study uses scientific journal publications in the last ten years as the object of research to describe the condition of nurses' understanding of type 2 diabetes mellitus, the nursing process of type 2 diabetes mellitus patients, and nursing training models based on needs analysis. The results of this systematic review revealed that most of the research journal articles focused on revealing the care of patients with diabetes mellitus by doctors, medical therapy for patients with diabetes mellitus, and comorbidities caused by diabetes mellitus. However, research on nursing training to intensify the implementation of the nursing process for patients with type 2 diabetes mellitus is still very rarely done. By observing this condition, research on the implementation of the nursing process for patients with type 2 diabetes mellitus based on analysis is very necessary to improve the quality of health services for patients with diabetes mellitus

Codesigned Shared Decision-Making Diabetes Management Plan Tool for Adolescents With Type 1 Diabetes Mellitus and Their Parents: Prototype Development and Pilot Test

Background: Adolescents with type 1 diabetes mellitus have difficulty achieving optimal glycemic control, partly due to competing priorities that interfere with diabetes self-care. Often, significant diabetes-related family conflict occurs, and adolescents’ thoughts and feelings about diabetes management may be disregarded. Patient-centered diabetes outcomes may be better when adolescents feel engaged in the decision-making process. Objective: The objective of our study was to codesign a clinic intervention using shared decision making for addressing diabetes self-care with an adolescent patient and parent advisory board. Methods: The patient and parent advisory board consisted of 6 adolescents (teens) between the ages 12 and 18 years with type 1 diabetes mellitus and their parents recruited through our institution’s Pediatric Diabetes Program. Teens and parents provided informed consent and participated in 1 or both of 2 patient and parent advisory board sessions, lasting 3 to 4 hours each. Session 1 topics were (1) patient-centered outcomes related to quality of life, parent-teen shared diabetes management, and shared family experiences; and (2) implementation and acceptability of a patient-centered diabetes care plan intervention where shared decision making was used. We analyzed audio recordings, notes, and other materials to identify and extract ideas relevant to the development of a patient-centered diabetes management plan. These data were visually coded into similar themes. We used the information to develop a prototype for a diabetes management plan tool that we pilot tested during session 2. Results: Session 1 identified 6 principal patient-centered quality-of-life measurement domains: stress, fear and worry, mealtime struggles, assumptions and judgments, feeling abnormal, and conflict. We determined 2 objectives to be principally important for a diabetes management plan intervention: (1) focusing the intervention on diabetes distress and conflict resolution strategies, and (2) working toward a verbalized common goal. In session 2, we created the diabetes management plan tool according to these findings and will use it in a clinical trial with the aim of assisting with patient-centered goal setting. Conclusions: Patients with type 1 diabetes mellitus can be effectively engaged and involved in patient-centered research design. Teens with type 1 diabetes mellitus prioritize reducing family conflict and fitting into their social milieu over health outcomes at this time in their lives. It is important to acknowledge this when designing interventions to improve health outcomes in teens with type 1 diabetes mellitus

Perbedaan Kadar Trigliserida Pada Penderita Diabetes Melitus Tipe 2 Dengan Hipertensi Dan Tanpa Hipertensi Di RSUD Moewardi

Background: Hypertension is common in patients with diabetes mellitus. Hypertension also increases the risk of cardiovascular disease in diabetes mellitus. High triglyserides level was a sign of dislipidemia. Diabetes mellitus and hypertension accompined with dislipidemia increased the risk of cardiovascular disease. Objective: This study aimed to know the difference of triglycerides level in diabetes mellitus type 2 with hypertension and non hpertension patients. Methods: This study was an observational analiytic with cross-sectional method using patiens medical record in Moewardi General Hospital in December 2014. Total sample was 100, divided into 2 groups of 50 diabetes mellitus type 2 with hypertension and 50 diabetes mellitus type 2 non hypertension groups. The sample were taken using purposive sampling method, then analyzed using Mann-Whitney test by SPSS 17.0 for windows. Result: The characteristics of diabetes mellitus type 2 in woman (51%) and men (49%) were not much different. The largest proportion of the age range is 56-65 years. Mann-Whitney test result was p=0.001 which means there is significant difference of triglycerides levels between two variables. Conclusion: Triglycerides levels in diabetes mellitus type 2 with hypertension is higher compared with diabetes mellitus type 2 non hypertension respondent

Evaluasi Kerasionalan Pengobatan Diabetes Melitus Tipe 2 Pada Pasien Rawat Inap Di Rsup Prof. Dr. R. D. Kandou Manado Tahun 2013

This study aimed to evaluating the rational of in patients Diabetes Mellitus type 2 medication in RSUP Prof. dr. R.D. Kandou Manado at 2013. This study was conducted on 46 medical record of patients of Diabetes Mellitus type 2. The result showed that 46 in patient Diabetes Mellitus type 2 in RSUP Prof. dr. R.D. Kandou Manado at 2013 were 51-60 years old (58,7%). Diabetes Mellitus type 2 patients comprised 16 men and 30 women. 15 cases (32,6%) were Diabetes Mellitus type 2 without complication diseases and 31 cases (67,4%) Diabetes Mellitus type 2 with complication diseases. Patients had indication appropriate were 40 patients (86,96%), drug choise appropriate 40 patients (100%). Dosis appropriate were 36 patients (97,32%), patient appropriate were 40 patients (100%), while for drug interaction not interaction

Diabetes mellitus in pregnancy, still changing

Objective: The management of pregnant women with diabetes mellitus places a significant burden on healthcare systems. Significant global changes have been proposed with regard to the diagnosis and management of women with diabetes mellitus in pregnancy. The study aims were to document the contemporary numbers, treatments and outcomes of diabetes mellitus in pregnancy, with particular focus on gestational and type 2 diabetes mellitus.Design, subjects and setting: A retrospective audit was performed of pregnant women (n = 278) with diabetes mellitus, managed over a 12-month period in a combined secondary and tertiary unit in South Africa.Results: Of the 278 cases analysed, 60% had gestational and 33% type 2 diabetes mellitus. The perinatal mortality ratio for all diabetes mellitus in pregnancy was 52.6:1 000, with only one early neonatal death. Ninety-five per cent and 70% of women with gestational and type 2 diabetes mellitus, respectively, were overweight or obese. Chronic hypertension was present in 23% of women with gestational and in 42% of women with type 2 diabetes mellitus. The glycosylated haemoglobin decreased from 6.7% at diagnosis to 6.4% at delivery in the gestational diabetes mellitus group, and from 7.5% at booking to 6.6% at delivery in the type 2 diabetes mellitus subjects. Lifestyle modification and metformin sufficed in 88% of women with gestational diabetes mellitus. Insulin was only required in 12% of pregnancies with gestational and in 53% of pregnancies with type 2 diabetes mellitus.Conclusion: Pregnancies complicated by gestational and type 2 diabetes mellitus are common and challenging. The addition of the oral agent, metformin, lowers the need for insulin therapy.Keywords: diabetes mellitus, glucose threshold, maternal and foetal health, pregnanc

DUKUNGAN KELUARGA PADA PASIEN DIABETES MELLITUS TIPE 2 DI KOTA SEMARANG

ntroduction: Diabetes mellitus is a chronic disease that is difficult to cure. This causes people with diabetes mellitus have psychological pressure. The family is one of the support systems for people with type 2 diabetes mellitus. This research aimed to know about family support of patients with type 2 diabetes mellitus.Method: The research is descriptive quantitative with cross sectional approach to know about family support in type 2 diabetes mellitus patients. The number of samples is 96 patients with type 2 diabetes mellitus at Regional Hospital KRMT Wongsonegoro Semarang.Results: The research showed that the family support of patients with type 2 diabetes mellitus had an average value of 61.52 with high level family support category of 70 respondents (72.9%) and low level family support category of 26 respondents (27.1%). Family support for patients who are married tends to be higher than single patients. Good family support will affect the implementation of the diabetes mellitus treatment program undertaken by the patient.Conclusion: Family support is an important factor in supporting the success of the type 2 diabetes mellitus treatment program. Therefore, nurses are expected to involve more families in providing nursing care to patients with type 2 diabetes mellitus.Keyword : Diabetes Mellitus, Family suppor

Risk Factors of Diabetes Mellitus in Rural Puducherry

Purpose: Prevalence of type 2 diabetes is increasing in India. Rural area constitutes 80% of India. Hence it is essential to understand the epidemiology for appropriate interventions. Objectives: to identify risk factors of type 2 diabetes mellitus in rural Puducherry. Methodology: Cross sectional study in two villages of Puducherry, India. 1403 subjects above 25 years from 2 villages. Study measured demographic variables, Body Mass Index (BMI), physical activity, family history of Diabetes Mellitus, smoking and alcohol consumption. Fasting blood glucose was measured for study subjects. Further, those with >126 mg/dl were subjected for Oral Glucose Tolerance Test. Univariate and multivariate analysis was done. Receiver Operating characteristic Curve was plotted to find out cut off for Diabetic Risk Score. Findings: The prevalence of type 2 Diabetes Mellitus (DM) was 5.8%. The response rate was (88%). In univariate analysis age, occupation, Socio Economic Status, BMI, physical activity, family history were significant for DM. In multivariate analysis age, BMI, family history of diabetes and occupation were significant for type 2 DM. The ‘diabetes risk score’ generated by the study using age, BMI and family history of DM, had specificity, sensitivity and accuracy of 54%, 77% and 76.2% respectively. The area under curve for scoring system was 0.784 (<0.05). Conclusions: Identified risk factors are useful for early diagnosis by using ‘diabetes risk score’ – thus uncovering the iceberg of disease