Intraosseous Schwannoma of the Jaws: An Updated Review of the Literature and Report of 2 New Cases Affecting the Mandible

Schwannomas are benign nerve sheath neoplasms composed almost entirely of Schwann cells. These tumors most often arise in the soft tissues of the head and neck. However, seldom do they occur within bone. This article presents a rare case of a recurrent intraosseous schwannoma of the anterior mandible and another case of a posterior intraosseous mandibular schwannoma accessed via a sagittal split ramus osteotomy. Furthermore, we provide an updated review of the literature on intraosseous schwannomas affecting the mandible and maxilla

Intraosseous Schwannoma (Neurilemmoma) of the Cervical Spine

Purpose: To report on an extremely rare tumour located in the cervical spine, its treatment and result. Review of the literature

Intraosseous Nerve Sheath Tumors in the Jaws

Although the head and neck region is recognized as the most common location for peripheral nerve sheath tumors, central involvement, particularly in the jaw bones, is quite unusual. Neurofibroma is one of the most common nerve sheath tumors occurring in the soft tissue and generally appears in neurofibromatosis 1 (NF1 or von Recklinghausen's disease). Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon sarcomas that almost always arise in the soft tissue. Here, we report four cases of intraosseous peripheral nerve sheath tumors occurring in the jaw bones and compare the clinical, radiologic, and pathologic findings in order to make a differential diagnosis

An Interdental Radiolucent Lesion of Mandible: A Case Report and Differential Diagnosis

Aim: The present article discusses a case which was an accidental finding in uncommon location. Case Report: A 70-year-old apparently healthy woman presented with proximal caries on mesial surface of canine and exhibited mild sensitivity to percussion. An intraoral periapical radiograph demonstrated interdental bone loss along with a diffuse unilocular radiolucent lesion between the canine and premolar region. Pathologies such as Radicular cyst,  Lateral Periodontal Cyst, Collateral Keratocystic Odontogenic Tumor (KCOT), Squamous Odontogenic Tumor (SOT), Central Giant Cell Granuloma (CGCG), Extrafollicular Adenomatoid Odontogenic Tumor (AOT), other possible odontogenic and mesenchymal lesions with similar presentation in the anterior jaw were considered and discussed in our differential diagnosis. Conclusion: After histopathological examination of the incisional biopsy, the lesion was diagnosed of KCOT. The lesion was treated with carnoy’s solution prior to surgical enucleation. The patient had been under regular follow-up for 2 years and showed no recurrence

Comparação dos padrões histopatológicos de casos em pacientes diagnosticados com Schwannoma/Neurilemmoma bucal em relação a localização acometida da lesão

Introdução: Revisão da literatura comparando padrões histopatológicos X localização, em casos de Schwannoma e/ou Neurilemmoma bucal. Metodologia: A base de dados utilizada foi Pubmed / Medline. Incluidos relatos de casos de Schwannoma/Neurilemmoma, os quais estivessem completos, contendo a idade, localização, gênero, histopatológico e imunoistoquimico. Reultados: Com a analise dos dados encontrados, constatamos que o gênero Feminino foi mais acometido, região mais afetada foi a língua, idade média encontrada foi de 33,46 anos, o padrão histopatológico encontrado com maior frequência foi a presença de padrões Antoni A e Antoni B juntos  (38 casos).  Conclusão:Observamos a importância da confirmação com imunoistoquimica + S-100

Solitary neurofibroma of the gingiva with prominent differentiation of Meissner bodies : a case report

<p>Abstract</p> <p>Background</p> <p>Oral neurofibromas are peripheral nerve sheath tumors, similar to schwannomas. Histological variations in oral neurofibromas are relatively uncommon.</p> <p>Case presentation</p> <p>Here, we present a case of unique variation in the observed characteristics of a neurofibroma, with no relation to neurofibromatosis type-1 or von Recklinghausen disease of the skin. The neurofibroma was observed in the right mandibular gingiva of a 32-year-old Japanese woman. Histologically, it differed from conventional neurofibromas in that the tumor was composed of a mixture of fine fibrillary collagen in sheets and/or cords of neoplastic Schwann cells containing numerous clusters of Meissner bodies. Histologically, these bodies were in contact with neoplastic Schwann cells. The Meissner bodies were immunopositive for S-100 protein, neuron-specific enolase, and vimentin, but were negative for calretinin. CD34-positive spindle cells were observed around the Meissner bodies. No recurrence or signs of other tumors have been observed in the patient for 5 years after tumor resection.</p> <p>Conclusion</p> <p>To the best of our knowledge, no formal descriptions of sporadic, solitary neurofibromas containing numerous Meissner bodies occurring in the oral cavity are available in literature. We believe that an uncommon proliferation of Meissner bodies, as seen in the present case, may result from aberrant differentiation of neoplastic Schwann cells.</p

Oral neural tumors : clinicopathologic analysis of 157 cases and review of the literature

Oral neural tumors (ONTs) are rare lesions and represent reactive or neoplastic proliferations of nerve sheath cells. The purpose of the present study is to report the clinical, demographic and histopathologic features of 157 ONTs diagnosed in a single Oral Pathology Department and review the pertinent literature. 157 cases of ONTs diagnosed during a 44-year period were retrospectively collected and the diagnosis was reconfirmed by studying representative haematoxylin and eosin stained tissue sections. The patients? gender and age, as well as the main clinical features of the lesions, were retrieved from the biopsy submission forms. The 157 ONTs represented approximately 0.4% of 35,590 biopsies accessioned during the study period. They affected 71 male and 86 female patients with a mean age of 38.4±18.8 years. They mainly appeared as asymptomatic nodules of normal or white colour on the tongue, lip mucosa and hard palate. The most common ONT was granular cell tumour (38.9%) followed by neurofibroma (19.7%), schwannoma (15.9%), traumatic neuroma (15.9%), palisaded encapsulated neuroma (8.3%) and nerve sheath myxoma (1.3%). This study confirmed the rarity of ONTs. Their clinical characteristics mimic other oral lesions; thus, microscopic examination is the only mean to arrive at a definitive diagnosis

A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study

The benign peripheral nerve sheath tumours are rare lesions mainly represented by schwannoma and neurofibroma. The present work evaluated the clinical and histopathological features of schwannomas and neurofibromas of the oral cavity diagnosed in a Brazilian population. Among 9.000 cases of oral lesions archived from 1970 to 2008, four schwannomas and 12 neurofibromas were identified, microscopically revised and immunohistochemically certified through a panel including monoclonal antibodies (anti-S100, vimentin, HHF-35 and desmin). From biopsy and histological sections records, clinical and histopathological data were retrieved, reviewed and statistically analysed. Predominantly, schwannomas affected non-white males (3:1), with an age and size averages of 34.7 years and 2.8 cm, respectively. Neurofibromas preferentially occurred on the gingival/alveolar ridge of white females (5:1), with 35.7-year mean age, peak of incidence between 3rd and 5th decade, and size average of 1.7 cm. (12 cases, 75%). The studied tumours exhibited more frequently as a painless, sessile and slow growth very similar to other oral lesions, but their microscopic features differed significantly. Schwannomas and neurofibromas are extremely uncommon in the oral cavity, exhibiting clinical features very similar but specific and peculiar microscopic findings that are useful in the establishment of the diagnosis, which in some particular cases must be confirmed by immunohistochemistry

A case report of neurofibromatosis

Introduction: Neurofibromatosis is a genetic disease characterized by multifocal benign tumors of peripheral nerves, called neurofibromas, and pigmented spots on the skin which inherited as autosomal-dominant. The most common form of the disease is neurofibromatosis type 1, also known as von Recklinghausen's disease of the skin. When an individual has small number of lesions in a limited region of the his body, it could be missed by the patient or not acknowledged by the clinicians as a form of neurofibromatosis. We present here, a case of an 18-year-old male with neurofibromatosis type 1who referred to Babol Dental School for a routine dental examination