Is COVID-19 pushing us to the fifth industrial revolution (Society 5.0)?

The coronavirus disease 2019 (COVID-19) pandemic may further promote the development of Industry 4.0 leading to the fifth industrial revolution (Society 5.0). Industry 4.0 technology such as Big Data (BD) and Artificial Intelligence (AI) may lead to a personalized system of healthcare in Pakistan. The final bridge between humans and machines is Society 5.0, also known as the super-smart society that employs AI in healthcare manufacturing and logistics. In this communication, we review various Industry 4.0 and Society 5.0 technologies including robotics and AI being inspected to control the rate of transmission of COVID-19 globally. We demonstrate the applicability of advanced information technologies including AI, BD, and Information of Technology (IoT) to healthcare. Lastly, we discuss the evolution of Industry 4.0 to Society 5.0 given the impact of the COVID-19 pandemic in accordance with the technological strategies being considered and employed

Corporate Social Responsibility Practices in Garments sector of Bangladesh, A Study of Multinational Garments, CSR view in Dhaka EPZ

This study has been conducted to explore the real scenario of present CSR practices by multinational companies of Bangladesh. Here we have assembled information from a renowned multinational company Hop lun (BD) as well as different secondary sources. After examining literature review and Hop lun (BD)’s information we can say that, today’s CSR practices is not spread properly. Some of organization trying their best, but in the most of cases organization are not aware about that. Without proper take care of society none of the business organization can’t go through their operation for long run. That’s why Hop Lun (BD) believes in CSR. And they are trying to do something for the further development of employee as well as stakeholders. We believe that social awareness can change the situation of Bangladesh. Government initiative and corporate organizations positive thinking can brand revolution positively in CSR. Keywords: CSR, Business, Banglades

Interaction between Science and Policy: Biodiversity and ecosystem services in city-regions

In this article, the National Institute on Biodiversity “Alexander von Humboldt” approaches the interaction between science and policy based on three case studies in which the Institute is advancing in mainstreaming biodiversity and ecosystem services into urban-regional planning. This project is coordinated by the Policy Program and actively supported by the Information and Knowledge Management and the Communication and Social Awareness programs of the Institute. The structure of this project is motivated by “integrative science” principles and is framed by the following institutional missions: (i) To strengthen scientific knowledge on BD and ESS based on robust and rigorous analysis and tools; (ii) To make this information valuable, indispensable and “readable” to policy-makers’ inquiries; and (iii) To spread scientific knowledge socially in order to promote citizens’ awareness and responsibility. Some of the questions to be solved or reconsidered during this research are: What information is needed to mainstream biodiversity and ecosystem services into urban-regional planning? How do we generate useful knowledge to society in order to reach real sustainability of and within cities? How do we integrate this knowledge into policy decisions? How do we make this information valuable to citizens? Policy agents are to be supported by technical inputs to analyze and model how BD and ESS respond to changes with uncertain degrees of intensity and consequences and how this affects human wellbeing and ecosystems’ sustainability. Taking into account these future scenarios, decision makers will be able to define and adopt policies and also promote social behaviors towards adaptability and resilience; therefore achieving real sustainable conditions. Policy makers need to understand that one of the most challenging issues to be resolved is to mainstream BD and ESS conservation outlines into urban policies and therefore advance in achieving real sustainability

Overview of lithium's use: a nationwide survey

BACKGROUND: Lithium is considered the gold standard treatment for bipolar disorder (BD). Current clinical guidelines and scientific evidence support its use as a first-line treatment in BD. However, over the last two decades, there has been a downward tendency in lithium's use in several developed countries. Based on a nationwide survey, this study's objective is to analyze in a large sample of psychiatrists relevant issues of the use of lithium salts in BD. METHODS: Data were collected through an anonymous survey sent by email among 500 psychiatrists who belong to a National Society of Psychiatry (Spanish Society of Biological Psychiatry). The survey is a self-administered questionnaire consisting of 21 items on the most key aspects of lithium's use (indication, dosage, monitoring, and information for patients). RESULTS: 212 psychiatrists completed the survey. 70% of psychiatrists prescribe lithium to more than 50% of patients diagnosed with BD. Adverse effects are the main reason not to use lithium salts. Over 75% of the participants consider lithium salts the treatment of choice for the maintenance phase of BD, both in women and men. Most of the participants (>50%) start lithium after the first affective episode, use conservative plasma concentrations (0.6-0.8mmol/L), and generally prescribe it twice a day. 57% of psychiatrists who treat patients under 18 do not use lithium in this population. About 70% of the survey respondents use official protocols to inform and monitor patients on lithium treatment. CONCLUSIONS: From the results of the present study, it can be concluded that the use of lithium in Spain is in line with the recommendations of the main international clinical guidelines and current scientific literature. The first reason not to prescribe lithium in our country is the perception of its adverse effects and not the aspects related to its practical use or its effectiveness. Considering that BD is a chronic disease with a typical onset in adolescence, the low rate of prescription of lithium salts in patients under 18 must be thoroughly studied.This work was supported by Carlos III Health Research Institute [Grant Number PI18/0155] (co-financed by the European Regional Development Fund (FEDER/ERDF)/European Social Fund 'Investing in your future'); Networking Center for Biomedical Research in Mental Health (CIBERSAM), the Basque Government [Grant number, 2017111104] and the University of the Basque Country [Grant Number 321212ELBY]. The psychiatric research department in Araba University Hospital is supported by the Stanley Research Foundation [Grant number 03-RC-003].

The project is completed! What now?: the Ancient Egyptian Book of the Dead: a digital Textzeugenarchiv

The Book of the Dead-Project Bonn started in the early 1990s. Prof Ursula Rößler-Köhler, who had previously laid the foundation for modern Book of the Dead studies by her work on BD chapter 17 applying the method of textual criticism, achieved a 10-year funding from the German Research Society (DFG). In 2004 the project was granted another 9-year funding by the Academy of Sciences and Arts of North Rhine-Westphalia. One aim of the project was to gather all available evidence of Book of the Dead manuscripts spread across collections around the world. Today, the archive comprises approximately 3000 records of BD sources. In 2012 the corresponding database, after undergoing a transfer from FileMaker to XML format in collaboration with the department of e-Humanities at the University of Cologne, was launched and made publicly available online. The data sets include various different kinds of information about the objects and the sets of BD spells and vignettes found on them. These are now easily accessible for statistic analyses such as evaluations of neighbouring spells and sequences or occurrences in specific locations or time periods. Furthermore, the database includes several metadata such as bibliographical information, translations of spells and a motif index. It is cross connected with other Egyptological databases such as Trismegistos and the Thesaurus Linguae Aegyptiae. After the project was completed at the end of 2012, the online database has been operating for a considerable amount of time with scholars using it and trying the several opportunities it provides. Now is the time for a first evaluation to actually see which functions of the database work well, which might have been ignored by users and what information the database could provide scholars with for their actual research. Naturally, there is a need for a continuous maintenance and update on new findings and the latest research. Furthermore it is important to understand which possibly missing functions or information the users wish to be included and if this is actually realisable. On the other hand, there might be opportunities for analyses that have not been fully understood and therefore have not been made use of. This presentation aims to address some of these issues concerning the BD online database and to gather ideas and possible collaborators for future BD project plans

Think individually, act collectively : studying the dynamics of a technologically enabled civic movement

The use of information and communication technologies pervades our lives. Beyond the formal application of these technologies at work, we have recently seen civil society groupings using information technologies to facilitate the organization and coordination of civic actions aiming at collective goals. This research in progress addresses the study of a technologically enabled civic movement wherein ordinary citizens supported and organized a civic action aiming at cleaning up the litter illegally dumped in their country's forests. Our preliminary results indicate that information and communication technologies had different roles throughout this process of organizing a nationwide civic action, which are influenced by the underlying dominant logic of action. This research contributes to a better understanding of the use of information and communication technologies as catalysts for change at societal level and its role in supporting entrepreneurial civic participation.FCT via Bolsa de Doutoramento SFRH/BD/60838/2009 and also support of Fundos Feder-COMPETE and FCT via FCOMP-01-0124-FEDER02267

Methodology for the integration of information, communication and automation technologies in housing rehabilitation

This paper addresses the integration of Information, Communication and Automation Technologies (ICAT) in the dwelling space in order to meet the user’s needs. We describe an ongoing PhD research which deals with the rehabilitation of the existing housing stock in order to fulfil the new needs of dwellers in the current Information Society as well as the impact of the integration of ICAT in dwellings. For this purpose we establish a rehabilitation methodology which enables architects to fulfil the client’s needs and requirements in home automation, from the beginning of the architectural process. This will enable the creation of a compatible and properly integrated ICAT infrastructure in homes,paving the way for ambient intelligence and promoting sustainable strategies at the environmental and social levels.The research described in this paper project was funded by the Portuguese Science Foundation (FCT) with grant SFRH / BD / 18225 / 2004

Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

Funding Information: Funding and additional information—C. G. A. has obtained funding from Maratona da Saúde 2016; CEECIND/00410/2017 financed by FCT (Portugal); ALZ AARG-19–618007 (Alzheimer’s Association); the European Union’s Horizon 2020 research and innovation program under grant agreement No 811087 (Lysocil). C. B. P. was the recipient of an FCT doctoral fellowship (PD/BD/128374/2017). T. B. is the recipient of an FCT doctoral fellowship (SFRH/BD/131513/ 2017). M. A. B. is the recipient of an FCT doctoral fellowship (2020.06758.BD). Funding Information: C. G. A. has obtained funding from Maratona da Sa?de 2016; CEECIND/00410/2017 financed by FCT (Portugal); ALZ AARG-19-618007 (Alzheimer's Association); the European Union's Horizon 2020 research and innovation program under grant agreement No 811087 (Lysocil). C. B. P. was the recipient of an FCT doctoral fellowship (PD/BD/128374/2017). T. B. is the recipient of an FCT doctoral fellowship (SFRH/BD/131513/ 2017). M. A. B. is the recipient of an FCT doctoral fellowship (2020.06758.BD). Funding Information: Acknowledgments—We thank M. Arpin (I Curie) and Z. Lenkei (ESPCI-ParisTech) for the gift of plasmids and cells, respectively. We thank Ana Cláudia Marques for her preliminary observations and lab members for helpful discussions and critical reading of the manuscript. We thank S. Marques (CEDOC Animal Facility), T. Pereira (CEDOC Microscopy Facility), and Ana Oliveira (CEDOC Cell Culture Facility) for their technical assistance. This project has received institutional funding from iNOVA4Health— UID/Multi/ 04462/2019; H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 - GA739572; the research infrastructure PPBI-POCI-01-0145-FEDER-022122, co-financed by FCT (Portugal) and Lisboa2020, under the PORTUGAL2020 agreement (European Regional Development Fund). Publisher Copyright: © 2021 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Genetic studies have identified BIN1 as the second most important risk locus associated with late-onset Alzheimer's disease (LOAD). However, it is unclear how mutation of this locus mechanistically promotes Alzheimer's disease (AD) pathology. Here we show the consequences of two coding variants in BIN1 (rs754834233 and rs138047593), both in terms of intracellular beta-amyloid (iAbeta) accumulation and early endosome enlargement, two interrelated early cytopathological AD phenotypes, supporting their association with LOAD risk. We previously found that Bin1 deficiency potentiates iAbeta production by enabling BACE1 cleavage of the amyloid precursor protein in enlarged early endosomes due to decreased BACE1 recycling. Here, we discovered that the expression of the two LOAD mutant forms of Bin1 does not rescue the iAbeta accumulation and early endosome enlargement induced by Bin1 knockdown and recovered by wild-type Bin1. Moreover, the overexpression of Bin1 mutants, but not wild-type Bin1, increased the iAbeta42 fragment by reducing the recycling of BACE1, which accumulated in early endosomes, recapitulating the phenotype of Bin1 knockdown. We showed that the mutations in Bin1 reduced its interaction with BACE1. The endocytic recycling of transferrin was similarly affected, indicating that Bin1 is a general regulator of endocytic recycling. These data demonstrate that the LOAD-coding variants in Bin1 lead to a loss of function in endocytic recycling, which may be an early causal mechanism of LOAD.publishersversionpublishe