Book Review: Politik und Gesellschaft im Kaukasus: Eine unruhige Region zwischen Tradition und Transformation

A review of Olaf Leiße, editor, Politik und Gesellschaft im Kaukasus: Eine unruhige Region zwischen Tradition und Transformation. Wiesbaden: Springer Verlag, 2019. x, 490 pages 978-3-658-26373-7; 978-3-658-26374-4 (eBook

GPS radio sources: new optical observations and an updated master list

* Aims. Identify optical counterparts, address uncertain identifications and measure previously unknown redshifts of the host galaxies of candidate GPS radio sources, and study their stellar populations. * Methods. Long slit spectroscopy and deep optical imaging in the B, V and R bands, obtained with the Very Large Telescope. * Results. We obtain new redshifts for B0316+161, B0407-658, B0904+039, B1433-040, and identify the optical counterparts of B0008-421 and B0742+103. We confirm the previous identification for B0316+161, B0407-658, B0554-026, and B0904+039, and find that the previous identification for B0914+114 is incorrect. Using updated published radio spectral information we classify as non GPS the following sources: B0407-658, B0437-454, B1648+015. The optical colors of typical GPS sources are consistent with single instantaneous burst stellar population models but do not yield useful information on age or metallicity. A new master list of GPS sources is presented.Comment: 10 pages + GPS master list. Accepeted for publication by A&

Vocabulary Learning Strategies of Japanese University Students

departmental bulletin pape

Going beyond Google: the invisible web in teaching and learning

Review of: Devine, J. and Egger-Sider, F. (2009) Going beyond Google: the invisible web in teaching and learning. London: Facet Publishing (ISBN 978-1-85604-658-9

An Experimental Study of a Flat Slab Floor Reinforced with Welded Wire Fabric

Reinforced Concrete Reserach CouncilOffice of the Chief of Engineers, U.S. Army.General Services Administration, Public Buildings ServiceHeadquarters, U.S. Air Force. Contract AF 33(658)-47U.S. Navy, Engineering Division. Bureau of Yards and Docks. NBy 3763

The Accelerating Pace of Juvenile Justice Reform

The pace of juvenile justice reform is accelerating across the nation. After a decade shaped by myths of juvenile "superpredators" and the ascendancy of harsh penalties and adult treatment for minors, momentum for systemic reform is growing.About half of the states are involved in some form of juvenile justice reform, often reversing punitive sanctions enacted in the 1980s and 1990s. Significant new research on public attitudes shows support for rehabilitating youthful offenders, and the demonstrated success of evidence-based practices is contributing to shifting the national debate.The tide is turning from a focus on harsh sanctions, automatic transfer to adult court, and removal of young people from their communities. What the public wants, and what the states are already developing, are rational and effective juvenile justice reforms that treat young people in developmentally appropriate ways

Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)

The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin) to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268–275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR) regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM), a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR