The 5C 6 and 5C 7 surveys of radio sources

5C 6 and 5C 7 continue the series of deep surveys made at 408 and 1407 MHz with the One-Mile telescope at Cambridge. They were intended (1) to provide a sample of faint radio sources suitable for further study; (2) to improve the statistics of source counts N(S) and spectral-index distributions at low flux densities; (3) to study the isotropy of the distribution of faint sources. Each observed field is about 4° in diameter at 408 MHz and 1° in diameter at 1407 MHz, and the field-centres are a α = 02ʰ14ᵐ, δ = 32° (5C 6) and α = 08ᵏ17ᵐ, δ = 27° (5C 7). The synthesized beamwidths (FWHM) are 80 arcsec (408 MHz) and 23 arcsec (1407 MHz). The techniques of observation and data-analysis followed closely those used for 5C 5 (Pearson, T. J., 1975. Mon. Not. R. astr. Soc., 171, 475), with some minor variations which are noted in Section 2

Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation

The serine protease subtilisin induces a form of long-term depression (LTD) which is accompanied by a reduced expression of the axo-dendritic guidance molecule Unco-ordinated-5C (Unc-5C). One objective of the present work was to determine whether a loss of Unc-5C function contributed to subtilisin-induced LTD by using Unc-5C antibodies in combination with the pore-forming agents Triton X-100 (0.005%) or streptolysin O in rat hippocampal slices. In addition we have assessed the effect of subtilisin on the related dependence receptor Deleted in Colorectal Cancer (DCC) and used antibodies to this protein for functional studies. Field excitatory postsynaptic potentials (fEPSPs) were analysed in rat hippocampal slices and protein extracts were used for Western blotting. Subtilisin produced a greater loss of DCC than of Unc-5C, but the antibodies had no effect on resting excitability or fEPSPs and did not modify subtilisin-induced LTD. However, antibodies to DCC but not Unc-5C did reduce the amplitude of theta-burst long-term potentiation (LTP). In addition, two inhibitors of endocytosis – dynasore and tat-gluR2(3Y) – were tested and, although the former compound had no effect on neurophysiological responses, tat-gluR2(3Y) did reduce the amplitude of subtilisin-induced LTD without affecting the expression of DCC or Unc-5C but with some loss of PostSynaptic Density Protein-95. The results support the view that the dependence receptor DCC may be involved in LTP and suggest that the endocytotic removal of a membrane protein or proteins may contribute to subtilisin-induced LTD, although it appears that neither Unc-5C nor DCC are involved in this process. (220)

Positive allosteric binding behavior of pyrene-appended triazole-modified thiacalix[4]arene-based fluorescent receptors

The novel heteroditopic receptors 5a∼c have been synthesized, which bear a thiacalix[4]arene in the 1,3-alternate conformation. Two urea moieties possessing various aryl groups with either electron-donating or -withdrawing groups at their p-positions function as anion-binding sites. At the opposite side of the cavity are two pyrene-appended triazole rings, which act as cation-binding sites. The binding property of receptor 5c was investigated by means of 1H NMR and UV–vis spectroscopy and by fluorescence titration experiments in the presence of various transition metal cations and anions in CH2Cl2–DMSO (10:1, v/v) solution. Interestingly, it was found that receptor 5c possessing two p-nitrophenyl ureido moieties, most efficiently complexes in the urea cavity or bistriazoles; the plausible allosteric effect of receptor 5c was also investigated

Light-Front Approach for Pentaquark Strong Decays

Assuming the two diquark structure for the pentaquark state as advocated in the Jaffe-Wilczek model, we study the strong decays of light and heavy parity-even pentaquark states using the light-front quark model in conjunction with the spectator approximation. The narrowness of the Theta width is ascribed to the p-wave configuration of the diquark pair. Taking the Theta width as a benchmark, we estimate the rates of the strong decays Xi_{3/2}-- to Xi- pi-, Sigma- K-, Sigma_{5c}0 to D_s- p, D_{s0}*- p and Xi_{5c}0 to D_s- Sigma+, D_{s0}^{*-} Sigma+ with Sigma_{5c} Xi_{5c} being antisextet charmed pentaquarks and D_{s0}* a scalar strange charmed meson. The ratio of Gamma(P_c to Baryon D_{s0}*)/Gamma(P_c to Baryon D_s) is very useful for verifying the parity of the antisextet charmed pentaquark P_c. It is expected to be of order unity for an even parity P_c and much less than one for an odd parity pentaquark.Comment: 24 pages, 2 figure

Author Correction: The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.

The originally published version of this Article contained errors in Figure 5, for which we apologise. In panel c, the scatter graph was inadvertently replaced with a scatter graph comprising a subset of data points from panel d. Furthermore, the legends to Figures 5c and 5d were inverted. These errors have now been corrected in both the PDF and HTML versions of the Article, and the incorrect version of Fig. 5c is presented in the Author Correction associated with this Article

Basic a final exam v4

Written exam for students who have completed Units 5C to 9D in the Face2Face Elementary Series published by Cambridge University Press

Spontaneous dehydrocoupling in peri-substituted phosphine-borane adducts

This work was financially supported by the EPSRC and COST action CM1302 SIPs.Bis(borane) adducts Acenap(PiPr2·BH3)(PRH·BH3) (Acenap = acenaphthene-5,6-diyl; 4a, R = Ph; 4b, R = ferrocenyl, Fc; 4c, R = H) were synthesised by the reaction of excess H3B·SMe2 with either phosphino-phosphonium salts [Acenap(PiPr2)(PR)]+Cl− (1a, R = Ph; 1b, R = Fc), or bis(phosphine) Acenap(PiPr2)(PH2) (3). Bis(borane) adducts 4a–c were found to undergo dihydrogen elimination at room temperature, this spontaneous catalyst-free phosphine-borane dehydrocoupling yields BH2 bridged species Acenap(PiPr2)(µ-BH2)(PR·BH3) (5a, R = Ph; 5b, R = Fc; 5c, R = H). Thermolysis of 5c results in loss of the terminal borane moiety to afford Acenap(PiPr2)(µ-BH2)(PH) (14). Single crystal X-ray structures of 3, 4b and 5a–c are reported.Publisher PDFPeer reviewe

Estimation of N-acetyltransferase 2 haplotypes

N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations. We have investigated haplotypes of 2088 subjects genotyped for NAT2 according to standard PCR/RFLP methods. In 856 out of 2088 cases the genotype was clearly defined by PCR/RFLP only. In many of the remaining cases the program clearly defined the most probable allele combination: In the case of *5A/*6C, *5B/*6A the probability for *5B/*6A is 99% whereas the alternative allele combination *5A/*6C can be neglected. Other combinations cannot be allocated with a comparable high probability. For example the allele combination *5A/*5C, *5B/*5D provides for *5A/*5C a probability of 69% whereas the estimation for *5B/*5D allele is only 31%. In the two most often observed constellations in our data [(*12A/*5B, *12C/*5C); (*12A/*6A, *12B/*6B, *4/*6C)] the probability of allele combination was ascertained as follows: *12A/*5B, 98%; *12C/*5C, 1.4% and *12A/*6A, 82%; *4/*6C, 17%; *12B/*6B, 0%. The estimation of the NAT2 haplotype is important because the assignment of the NAT2 alleles *12A, *12B or *13 as a rapid or slow genotype has been discussed controversially. Otherwise the classification of alleles in subjects which are not showing a clearly allocation can result in a rapid or slow acetylation state. This assignment has an important role in survey of bladder cancer cases in the scope of occupational exposure with aromatic amines. --PHASE 2.1,NAT2 genotyping,single nucleotide polymorphism

Pengaruh Penyuluhan terhadap Pengetahuan dan Sikap 5R (Ringkas, Rapi, Resik, Rawat, Rajin) pada Tenaga Kerja di Sentra Industri Pengrajin Blangkon Serengan Surakarta

The application of 5C be applied throughout the industrial sector, both formal and informal industry. Lack of information on 5C in the industrial sector informal impact on the lack of knowledge and attitude 5C on workers. The purpose of this research was to analyze the influence of councelling to knowledge and attitude about 5C on mployee’s blangkon industry centre, Serengan Surakarta. This research’s method used quasi experimental by one group pretest and posttest. The population in this research was blangkon craftsman employee’s about 88 workers. The sample technique used proportional sampling technique as many as 47 respondents. The result of this research showed an increase in the average score at the knowledge before and after treatment as many as 44.2 %. In the attitude showed an increase in the average score before and after treatment as many as 54.3 %. The results of statistical tests used wilcoxon on knowledge shows p value 0.000 and in the attitude of shows p value 0.000 wich mean ≤ 0.05, so it can be concluded that there is influence of counselling to the knowledge and attitude about 5C on employee’s blangkon industry centre, Serengan Surakarta. The advice to employee’s is to be more enterprising in the tracery of related information about 5C so can be applied 5C at work place and to the government to conduct counselling further so that employee’s can understand more about the purposes of 5C. Keywords : Councelling, 5C ( Clear-out, Configure, Clean, Conform, Custom ), Knowledge, Attitude

Incivility (Hate Speech/Incivility)

The variable incivility is an indicator used to describe violations of communication norms. These norms can be social norms established within a society, a culture or parts of a society (e.g. a social class, milieu or group) or democratic norms established within a democratic society. In this sense incivility is associated with behaviors that threaten a collective face or a democratic society, deny people their personal freedoms, and stereotype individuals or social groups. Furthermore, some scholars include impoliteness into the concept of incivility and argue that the two concepts have no clear boundaries (e.g. Seely, 2017). They therefore describe incivility as aggressive, offensive or derogatory communication expressed directly or indirectly to other individuals or parties. In many studies a message is classified as uncivil if the message contains at least one instance of incivility (e.g. one violent threat). The direction of an uncivil statement is coded as ‘interpersonal’/‘personal’ or ‘other-oriented’/‘impersonal’ or sometimes also as ‘neutral’, meaning it is not directed at any group or individual. Field of application/theoretical foundation: One unifying element to communication that is labelled as incivility is that it has to be a violation of an existing norm. Which norms are seen as violated depends on the theoretical tradition. Incivility research is related to theories on social norms of communication and conversation: conversational-maxims (Grice, 1975), face-saving concepts (Brown & Levinson, 1987; Goffman, 1989) or conversational-contract theories (Fraser, 1990). Further, incivility research has ties to theories that view public communication as part of democratic opinion formation and decision-making processes, e.g. theories on deliberative democracy and deliberation (Dryzek, 2000; Gutmann & Thompson, 1996; Habermas, 1994). References/combination with other methods of data collection: Incivility is examined through content analysis and sometimes combined with comparative designs (e.g., Rowe, 2015) or experimental designs (Muddiman, 2017; Oz, Zheng, & Chen, 2017). In addition, content analyses can be accompanied by interviews or surveys, for example to validate the results of the content analysis (Erjavec & Kovačič, 2012). Example studies: Research question/research interest: Previous studies have been interested in the extent, levels and direction of incivility in online communication (e.g. in one specific online discussion, in discussions on a specific topic, in discussions on a specific platform or on different platforms comparatively). Object of analysis: Previous studies have investigated incivility in user comments on political newsgroups, news websites, social media platforms (e.g. Twitter, Facebook), political blogs, science blogs or online consultation platforms. Timeframe of analysis: Many studies investigate incivility in user comments focusing on periods between 2 months and 1 year. It is common to use constructed weeks. Level of analysis: Most manual content analyses measure incivility on the level of a message, for example on the level of user comments. On a higher level of analysis, the level of incivility for a whole discussion thread or online platform can be measured or estimated. On a lower level of analysis incivility can be measured on the level of utterances, sentences or words which are the preferred levels of analysis in automated content analyses. Table 1. Previous manual content analysis studies and measures of incivility Example study Construct Dimensions/Variables Explanation/example Reliability Papacharissi (2004) incivility (separate from impoliteness) threat to democracy e.g. propose to overthrow a democratic government by force Ir = .89 stereotype e.g. association of a person with a group by using labels, whether those are mild – “liberal”, or more offensive – “faggot”)? Ir = .91 threat to other individuals’ rights e.g. personal freedom, freedom to speak Ir = .86 incivility Ir = .89 Coe, Kenski, and Rains (2014) incivility (impoliteness is included) name-calling mean-spirited or disparaging words directed at a person or group of people K-α = .67 aspersion mean-spirited or disparaging words directed at an idea, plan, policy, or behavior K-α = .61 reference to lying stating or implying that an idea, plan, or policy was disingenuous K-α = .73 vulgarity using profanity or language that would not be considered proper (e.g., “pissed”, “screw”) in professional discourse K-α = .91 pejorative for speech disparaging remark about the way in which a person communicates K-α = .74 incivility / impoliteness K-α = .73 Rowe (2015) incivility (separate from impoliteness) threat to democracy proposes to overthrow the government (e.g. proposes a revolution) or advocates an armed struggle in opposition to the government (e.g. threatens the use of violence against the government) κ = .66 threat to individual rights advocates restricting the rights or freedoms of certain members of society or certain individuals κ = .86 stereotype asserts a widely held but fixed and oversimplified image or idea of a particular type of person κ = .80 incivility κ = .77 Seely (2017) incivility(impoliteness is included) insulting language name calling and other derogatory remarks often seen in pejorative speech and aspersions K-α = .84 vulgarity e.g. “lazy f**kers”, “a**holes” K-α = 1 stereotyping of political party/ideology e.g. “typical lying lefties” K-α = .88 stereotyping using “isms”/discriminatory language e.g. “if we don’t get rid of idiotic Muslim theologies, we will have growing problems” K-α = 1 other stereotyping language e.g. “GENERALS LIKE TO HAVE A MALE SOLDIER ON THEIR LAP AT ALL TIMES.” K-α = .78 sarcasm e.g. “betrayed again by the Repub leadership . . . what a shock” K-α = .79 accusations of lying e.g. “typical lying lefties” K-α = .80 shouting excessive capitalization and/or exclamation points K-α = .83 incivility / impoliteness K-α = .81 Note: Previous studies used different inter-coder reliability statistics; Ir = reliability index by Perreault and Leigh (1989); K-α = Krippendorff’s-α; κ = Cohen’s Kappa   Codebook used in the study Rowe (2015) is available under: https://www.tandfonline.com/doi/full/10.1080/1369118X.2014.940365   References Brown, P., & Levinson, S. C. (1987). Politeness: Some universals in language usage. Cambridge: Cambridge University Press. Coe, K., Kenski, K., & Rains, S. A. (2014). Online and Uncivil? Patterns and Determinants of Incivility in Newspaper Website Comments. Journal of Communication, 64(4), 658–679. https://doi.org/10.1111/jcom.12104 Dryzek, J. S. (2000). Deliberative democracy and beyond: Liberals, Critics, Contestations. Oxford political theory. Oxford, New York: Oxford University Press. Erjavec, K., & Kovačič, M. P. (2012). “You Don't Understand, This is a New War! ” Analysis of Hate Speech in News Web Sites' Comments. Mass Communication and Society, 15(6), 899–920. https://doi.org/10.1080/15205436.2011.619679 Fraser, B. (1990). Perspectives on politeness. Journal of Pragmatics, 14(2), 219–236. https://doi.org/10.1016/0378-2166(90)90081-n Goffman, E. (1989). Interaction ritual: Essays on face-to-face behavior. New York: Pantheon Books. Grice, P. H. (1975). Logic and conversation. In P. Cole (Ed.), Syntax and Semantics: Speech acts (pp. 41–58). New York: Academic Press. Gutmann, A., & Thompson, D. F. (1996). Democracy and disagreement. Cambridge, Massachusetts: Belknap Press of Harvard University Press. Habermas, J. (1994). Three Normative Models of Democracy. Constellations, 1(1), 1–10. Muddiman, A. (2017). : Personal and public levels of political incivility. International Journal of Communication, 11, 3182–3202. Oz, M., Zheng, P., & Chen, G. M. (2017). Twitter versus Facebook: Comparing incivility, impoliteness, and deliberative attributes. New Media & Society, 20(9), 3400–3419. https://doi.org/10.1177/1461444817749516 Papacharissi, Z. (2004). Democracy online: Civility, politeness, and the democratic potential of online political discussion groups. New Media & Society, 6(2), 259–283. https://doi.org/10.1177/1461444804041444 Rowe, I. (2015). Civility 2.0: A comparative analysis of incivility in online political discussion. Information, Communication & Society, 18(2), 121–138. https://doi.org/10.1080/1369118X.2014.940365 Seely, N. (2017). Virtual Vitriol: A Comparative Analysis of Incivility Within Political News Discussion Forums. Electronic News, 12(1), 42–61. https://doi.org/10.1177/193124311773906