The Influence of Fasting and Energy Restricting Diets on IGF-1 Levels in Humans: A Systematic Review and Meta-Analysis

Background: Fasting and energy restricting diets have a potential means of delaying or preventing the onset of a range of age-related metabolic and neoplastic diseases. Consistently at the centre of this effect appears to be a significant reduction in circulating IGF-1 levels. The aim of the current systematic review and meta-analysis was to determine the influence of fasting and energy restriction on IGF-1 levels in human subjects. Methods: A comprehensive systematic search was conducted from onset of the database to February 2019 in Embase, MEDLINE/PubMed, and SCOPUS to identify randomized clinical trials that investigating the impact of fasting or energy restriction circulating IGF-1 levels. Effect size was reported as weighted mean difference (WMD) and 95 confidence intervals (CI) using a random-effects models. Subgroup analysis was performed to identify the probable source of heterogeneity among trials. Results: Total pooling of fasting and energy restriction randomised controlled trials in WMD analysis revealed no significant effect on circulating IGF-1 levels (WMD: �16.41 ng/ml, 95 CI: �35.88, 3.07). Sub grouped analysis fasting regimens appeared to substantially reduce IGF-1 (WMD: -28.87 ng/ml, 95 CI: �43.69, �14.05, I 2 = 00), energy restricting regimens failed to do the same (WMD: -10.98 ng/ml, 95 CI: �33.08, 11.11, I 2 = 90). Within this final subgrouping, it was observed that only energy restriction regimens of 50 or greater of normal daily energy intake were capable of significantly reducing IGF-1 levels (WMD: -36.57 ng/ml, 95 CI: �59.19, �13.95, I 2 = 00). Finally, a meta regression were noted in which the percentage restriction of daily energy intake inversely correlated with plasma IGF-1 levels (p = 0.04). Conclusion: This study uncovered that fasting significantly reduced levels of IGF-1, while energy restriction diets were successful only when intake was reduced by 50 or more. © 2019 Elsevier B.V

ExoMol molecular line lists XXX: a complete high-accuracy line list for water

A new line list for H$_2$$^{16}$O is presented. This line list, which is called POKAZATEL, includes transitions between rotation-vibrational energy levels up to 41000 cm$^{-1}$ in energy and is the most complete to date. The potential energy surface (PES) used for producing the line list was obtained by fitting a high-quality ab initio PES to experimental energy levels with energies of 41000 cm$^{-1}$ and for rotational excitations up to $J=5$. The final line list comprises all energy levels up to 41000 cm$^{-1}$ and rotational angular momentum $J$ up to 72. An accurate ab initio dipole moment surface (DMS) was used for the calculation of line intensities and reproduces high-precision experimental intensity data with an accuracy close to 1 %. The final line list uses empirical energy levels whenever they are available, to ensure that line positions are reproduced as accurately as possible. The POKAZATEL line list contains over 5 billion transitions and is available from the ExoMol website (www.exomol.com) and the CDS database

Effect of different energy levels diet on oocyte quantity and quality of non lactating cows (Bos indicus and Bos taurus) submitted to ovum pick-up.

Supl.2. Edição dos resumos da 24a Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Porto de Galinhas, 2010

Spectroscopically determined potential energy surface of H216O up to 25 000 cm–1

A potential energy surface for the major isotopomer of water is constructed by fitting to observed vibration–rotation energy levels of the system using the exact kinetic energy operator nuclear motion program DVR3D. The starting point for the fit is the ab initio Born–Oppenheimer surface of Partridge and Schwenke [J. Chem. Phys. 106, 4618 (1997)] and corrections to it: both one- and two-electron relativistic effects, a correction to the height of the barrier to linearity, allowance for the Lamb shift and the inclusion of both adiabatic and nonadiabatic non-Born–Oppenheimer corrections. Fits are made by scaling the starting potential by a morphing function, the parameters of which are optimized. Two fitted potentials are presented which only differ significantly in their treatment of rotational nonadiabatic effects. Energy levels up to 25 468 cm–1 with J = 0, 2, and 5 are fitted with only 20 parameters. The resulting potentials predict experimentally known levels with J≤10 with a standard deviation of 0.1 cm–1, and are only slightly worse for J = 20, for which rotational nonadiabatic effects are significant. The fits showed that around 100 known energy levels are probably the result of misassignments. Analysis of misassigned levels above 20 000 cm–1 leads to the reassignment of 23 transitions

QED correction for H3+_3^+

A quantum electrodynamics (QED) correction surface for the simplest polyatomic and polyelectronic system H$_3^+$ is computed using an approximate procedure. This surface is used to calculate the shifts to vibration-rotation energy levels due to QED; such shifts have a magnitude of up to 0.25 cm$^{-1}$ for vibrational levels up to 15~000 cm$^{-1}$ and are expected to have an accuracy of about 0.02 cm$^{-1}$. Combining the new H$_3^+$ QED correction surface with existing highly accurate Born-Oppenheimer (BO), relativistic and adiabatic components suggests that deviations of the resulting {\it ab initio} energy levels from observed ones are largely due to non-adiabatic effects

Energy Levels and Wave Functions of Vector Bosons in Homogeneous Magnetic Field

We aimed to obtain the energy levels of spin-1 particles moving in a constant magnetic field. The method used here is completely algebraic. In the process to obtain the energy levels the wave function is choosen in terms of Laguerre Polynomials.Comment: 13 pages, no figure

The Fractional Quantum Hall States of Dirac Electrons in Graphene

We have investigated the fractional quantum Hall states for the Dirac electrons in a graphene layer in different Landau levels. The relativistic nature of the energy dispersion relation of the electrons in the graphene significantly modifies the inter-electron interactions. This results in a specific dependence of the ground state energy and the energy gaps for electrons on the Landau level index. For the valley-polarized states, i.e. at \nu =1/m, m being an odd integer, the energy gaps have the largest values in the n=1 Landau level. For the valley-unpolarized states, e.g., for the 2/3 state, the energy gaps are suppressed for the n=1 Landau level as compared to the n=0 level. For both the n=1 and n=0 Landau levels the ground state of the 2/3 system is fully valley-unpolarized.Comment: accepted for publication in Phys. Rev. Let