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Exploring S-Nitrosoglutathione reductase function in the non-vascular plant, Marchantia polymorpha

Abstract

A key feature of plant immunity is the rapid engagement of a burst of nitric oxide (NO) following pathogen recognition. In addition to direct antimicrobial activity NO also orchestrates a plethora of signalling functions to control the deployment of plant immune responses. The predominant route for NO signalling is S-nitrosylation, a key redox-based, post-translational modification involving the addition of a NO moiety to a protein cysteine (Cys) thiol, forming an S-nitrosothiol (SNO). To explore a potential role for S-nitrosylation in the immune system of early land plants, we identified a single-copy S-nitrosoglutathione reductase 1 (GSNOR1) gene in Marchantia polymorpha (Mp) and introduced loss-of-function mutations using the CRISPR/Cas9 gene editing method to explore the potential function of GSNOR in this early land plant. We observed distinct morphological changes in Mp resulting from the absence of GSNOR1 function, providing new insights into the structural adaptations of this plant. In addition, we found GSNOR1 plays a central role in the immune system of Mp. This research contributes to a broader understanding of plant-microbe interactions. It offers a fundamental understanding of the function of NO and GSNOR1 in Mp development and immunity and also provides insights into evolutionary plant biology

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Edinburgh Research Archive

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Last time updated on 13/05/2024

This paper was published in Edinburgh Research Archive.

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