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Supporting information for methods and results.
Abstract
Supplemental materials for PrePROTAC model training, testing and prediction. Additional results for eSHAP analysis on the human protein kinases. (PDF)</p- Text
- Journal contribution
- Biochemistry
- Genetics
- Molecular Biology
- Biotechnology
- Cancer
- Biological Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- Information Systems not elsewhere classified
- xlink "> proteolysis
- random forest classification
- play critical roles
- identify key residues
- false positive rate
- different structural folds
- alzheimer &# 8217
- external test set
- entire human genome
- proposed protac compounds
- method allowed us
- identified key residues
- preprotac predicts genome
- training set
- wide targets
- using preprotac
- targeting chimeras
- small molecules
- silico mutagenesis
- remains unclear
- related genes
- protein structure
- protac activity
- promising therapy
- preprotac achieved
- potentially degradable
- original features
- incurable diseases
- inactivate disease
- experimentally tested
- existing knowledge
- embedding space
- e3 ligases
- e3 ligase
- drop significantly
- considered undruggable
- bifunctional molecules
- benchmark studies
- average precision
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Last time updated on 20/08/2023
This paper was published in The Francis Crick Institute.
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