Interactions between predicted PROTACs and the CRBN-target protein complex structures.

Abstract

(a) Ligand-target Interactions between CRBN and its crystallized ligand LVY in 4TZ4. (b) 2D Ligand-target Interactions between CRBN and its crystallized ligand LVY in 4TZ4. C represents the PDB chain ID for CRBN. (c) Ligand-target interactions between PROTAC3269 and the complex structure of P12757 and CRBN. (d) 2D Ligand-target interactions between PROTAC3269 and the complex structure of P12757 and CRBN. A represents the chain ID for the target protein. B represents the chain ID for CRBN. (e) Ligand-target interactions between PROTAC3055 and the complex structure of Q9UER7 and CRBN. (f) 2D Ligand-target interactions between PROTAC3055 and the complex structure of Q9UER7 and CRBN. C represents the chain ID for the target protein. B represents the chain ID for CRBN. (g) Ligand-target interactions between PROTAC2145 and the complex structure of Q9H1I8 and CRBN. (h) 2D Ligand-target interactions between PROTAC2145 and the complex structure of Q9H1I8 and CRBN. A represents the chain ID for the target protein. B represents the chain ID for CRBN. Cyan and green sticks represent interacting residues on CRBN and the target protein, respectively. Yellow balls and sticks represent the ligand structures. Color representations for the interaction types are shown in figure legend.</p