Repository landing page

We are not able to resolve this OAI Identifier to the repository landing page. If you are the repository manager for this record, please head to the Dashboard and adjust the settings.

Optimizing treatment for airways diseases:Using exhaled biomarkers and real world data

Abstract

Airways diseases are complex and difficult to treat due to the heterogeneity of their etiology. Treatment is typically based on clinical characteristics, and best treatment practices may not necessarily be beneficial for individual patients. Better stratification and timing of medical interventions is possible by adopting an approach that utilizes biological information and disease biomarkers. The identification of differences between patient groups holds potential to improve treatment. This thesis has two main aims: further developing methods that explore the use of biomarkers in (chronic) airway diseases, and exploring the feasibility and application of strategies to collect real-world evidence in patients with severe asthma. Current most well-known biomarkers in chronic airways diseases have predictive value for treatment response to corticosteroid drugs, but their use is limited. We explored the ability of exhaled breath measurement to detect recent exacerbations in COPD and asthma patients using electronic nose (eNose) devices. The studies showed that exhaled breath analysis could identify COPD and asthma patients who recently had an exacerbation with high accuracy, suggesting a possible role in monitoring.In the second part, we found differences between eligibility criteria for anti-IL5 drug trial participation and registry data of patients who started this therapy, however 50% of OCS-dependent patients were able to reduce their dose to ≤5 mg prednisone per day. Within the SHARP consortium we found a large variation in characteristics and lifestyle-associated factors in different severe asthma registries across Europe. Suggesting the severe asthma population and their treatment are heterogenous across Europe and diagnosis in clinical practice differs across countries

Similar works

Full text

thumbnail-image

International Migration, Integration and Social Cohesion online publications

redirect
Last time updated on 08/03/2023

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.