雌性Fischer344系ラットヒラメ筋におけるミオシン重鎖アイソフォーム構成比の加齢変化

Abstract

We studied a change of myosin heavy chain (MyHC) isoform composition by aging in female Fischer344 rats soleus muscles. Three (N=6)-， six (N=6)-， twelve (N=6)-， twenty (N=7)- and twenty-sevens (N=6)-month old female rats were examined. The weight of soleus muscle was not changed with aging. The relative weight of soleus muscle was not changed from 3-month-old to 12-month-old. But， the relative weight in 20- and 27-month old was significantly lower than 3- month old. The existence of type II a MyHC was identified， and this isoform composition was not different by 12-month old from 3-month old. But， it was not possible to identified existence of type II a MyHC in 20- and 27-month old. These results indicated that the changes by aging would be different from about 20-month in female Fischer344 rat soleus muscle.departmental bulletin pape