BSTRACT
Introduction: Hepatitis B infection is an important health problem all over the world, and
according to the studies, Iran is a country with intermediate prevalence, so vaccination is a
cost‑benefit approach. In this study, evidence about the efficacy of hepatitis B vaccine was
collected by systematic review methods and its amount was estimated by a meta‑analysis.
Materials and Methods: In this study, documents and literature search were performed
using valid key words in Information Sciences Institute, PubMed, Scientific Information
Data base, and Iranmedex databases from 1997 to 2010 in different regions of Iran. All
cross‑sectional studies about the efficacy of hepatitis B vaccine in Iran which fulfilled
the inclusion criteria entered the study. Antibody titer (Anti‑hemoglobins > 10 IU/L) was
considered as the desired efficacy. In order to present the results, prevalence and Forest
plot were used and for evaluation of the inconsistency meta‑regression model and I2 index
were used. We used R.15.3.2 software for analysis. Results: Totally 64 studies (52 studies
in general population and 12 studies among specific populations) including 12,575 subjects
with age range from 8 months to 55 years entered the meta‑analysis. The efficacy was
86.3% (confidence interval [CI]: 83.9‑88.7%) in the general population and 59.62% (CI:
47.9‑71.29%) in specific patient populations. Also the efficacy was significantly related to the
year of publication, age and gender (P < 0.05). Conclusion: Prevention is an important issue
in general health. Hepatitis B vaccination is one of the methods used to prevent hepatitis
B infection. According to this study, the efficacy of hepatitis B vaccination was more than
80% in general population, so injection of full course of hepatitis B vaccinationis enough
and booster dose is not required.
Key words: Hepatitis B, meta‑analysis, meta‑regression, systematic review, vaccin
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