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Molecular and clinic-pathological features of 138 ECs.
Abstract
<p>(A) Molecular and clinic–pathological landscape of 138 ECs. Genetic analysis, focusing on frequent hotspot mutations in the POLE gene, and MSI status result in the identification of three molecular subgroups: (1) <i>POLE</i>-mutant, (2) MSI and (3) non-MSI. (B) Progression-free survival and endometrial cancer-specific survival of 138 EC patients stratified by genetic profiles. <i>P</i> values were calculated by the log-rank test.</p- Image
- Figure
- Biophysics
- Biochemistry
- Cell Biology
- Genetics
- Molecular Biology
- Biotechnology
- Cancer
- bisulfite polymerase chain reaction
- MSI status
- EC patients
- KRAS
- endometrial cancer-specific survival
- IHC
- PCR
- POLE mutations
- endometrial cancer
- MLH 1 deficiency
- MMR proficiency
- 138 EC patients
- microsatellite instability Background
- MSI analysis
- MLH 1 promoter