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Effect of vaccination of humans with subunit influenza vaccines on Treg frequency.
Abstract
<p>At day 0, healthy adults were i.m. vaccinated with a non-adjuvanted (Agrippal<sup>®</sup>) or MF59<sup>®</sup>-adjuvanted (Fluad<sup>®</sup>) trivalent influenza subunit vaccine or injected with a placebo. At day 1, 3, 5, 14 and 21 post vaccination changes in Treg frequency were determined. The delta Treg percentage per time point was determined per donor (= % Treg day<sub>x</sub>—% Treg day<sub>0</sub>). Mean (± SEM) delta percentage of the frequency of rTreg (left) and aTreg (right) in the blood at the different time points after vaccination with Agrippal<sup>®</sup> (n = 12), Fluad<sup>®</sup> (n = 8, day 14 n = 2) or placebo (n = 6). Means were statistically compared with a Kruskal-Wallis test.</p- Image
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- activation marker CD 25
- Treg frequency
- vaccine virus replication
- functionality marker CD 39
- adjuvanted hepatitis B subunit vaccine
- hepatitis B vaccine
- MF
- CD 4
- lymph nodes
- Regulatory T cell frequencies
- influenza subunit vaccine
- phenotype
- vaccination Regulatory T cells
- Treg frequencies
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Last time updated on 08/04/2018
This paper was published in The Francis Crick Institute.
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