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Schematic diagram showing the course of CRS inducing abnormal activation of primordial follicles.
Abstract
<p>CRS leads to the excessive activation of primordial follicles, accompanied by up-regulated expression of Kitl and its receptor Kit, and the activation of PI3K/PTEN/Akt pathway. What is more, the level of serum AMH was increased significantly after CRS. CRH induced by chronic stress might play an important role in the activation and exhaustion of primordial follicles. CRS, Chronic restraint stress.</p- Image
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- Biochemistry
- Cell Biology
- Genetics
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- Developmental Biology
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- Biological Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- serum CRH
- receptor Kit
- Kit ligand
- activation
- corticotropin-releasing hormone
- PTEN
- Chronic restraint stress
- CRS group
- control group
- follicle development
- mice ovaries Chronic stress
- chromosome 10
- restraint stress
- causes endocrinal disorders
- CRS mouse model
- receptor CRHR 1increased
- 8 weeks
- expression level
- mouse ovaries
- PI 3K
- mouse model
- Kit-PI 3K
- CRS mouse group
- tensin homolog
- phosphatidylinositol 3- kinase
- 100 nM CRH
- polymerase chain reaction assay
- mRNA level
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Last time updated on 08/04/2018
This paper was published in The Francis Crick Institute.
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