Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy-2

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy"</p><p>http://www.biomedcentral.com/1471-2164/8/268</p><p>BMC Genomics 2007;8():268-268.</p><p>Published online 7 Aug 2007</p><p>PMCID:PMC1964766.</p><p></p>ted pathways are: Oxidative Phosphorylation (cluster 1), containing 16 genes downregulated in trisomic samples, and Focal Adhesion (cluster 2), containing at least 7 genes upregulated in trisomic samples. Cluster 3 is a network of Cell Adhesion genes, mostly upregulated in trisomic samples. Downregulated genes in cluster 1 are all mitochondrial genes; upregulated genes in clusters 2 and 3 are mostly ECM genes. Green indicates downregulated genes (darker green = more downregulated); red indicates upregulated genes (darker red = more upregulated)