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Cage-Catalyzed Knoevenagel Condensation under Neutral Conditions in Water
Abstract
A cationic coordination cage dramatically accelerates the Knoevenagel condensation of aromatic aldehydes in water under neutral conditions. The addition of a nucleophile to the aldehyde to generate anionic intermediates seems to be facilitated by the cationic environment of the cavity. The products are ejected from the cage as a result of the host–guest size discrepancy. As a result, the condensation is promoted by a catalytic amount of the cage- Text
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- Biochemistry
- Genetics
- Molecular Biology
- Neuroscience
- Evolutionary Biology
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- Inorganic Chemistry
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- Neutral Conditions
- cationic environment
- Knoevenagel condensation
- WaterA cationic coordination cage
- aldehyde
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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