Replication of the association of rs207650 in TOMM40/APOE.

Abstract

<p>The table shows the replicated associations of the SNP rs207650 in <i>TOMM40/APOE</i> in the replication set 1 and the additional control set from the Parkinson's Disease study. Column legends: <b>SNP</b> = official dbSNP identifier. <b>Gene</b> = official gene name for SNPs that are within 20 kb from transcribed regions. <b>Chrom</b> = Chromosome and physical position of SNP in hg18. <b>Alleles</b> = the two SNP alleles (allele 1 v allele 2) in the genetic model that reached strongest significance in the Bayesian analysis. <b>LOG10(BF)</b> = the logarithm 10 Bayes Factor for the association relative to the null model of no association. Assuming uniform prior probabilities for the two hypotheses, the BF represents the posterior odds for association. <b>P-value</b> = p-value for 1 degree of freedom test for the dominant model AG/GG versus AA. <b>OR</b> = odds ratio for exceptional longevity in subjects who carry allele 1 relative to allele 2. For example, subjects who carry the allele 1 (AG/GG) of SNP rs2075650 have 0.49 times the odds for exceptional longevity compared to subjects who carry the allele 2 (AG/GG: either the genotype AG or GG). <b>P(A)</b> = prevalence of allele 1 in cases and controls. For example, 15% of centenarians carry the allele AG/GG of SNP rs2075650 compared to 26% of controls. Row 1 shows the results in the discovery set; row 2 in the ELIX set, row 3 the combined discovery and ELIX datasets and row 4 is the set in which the 914 matched controls of the discovery set were replaced with the unmatched Coriel controls.</p