Comparison of individualized metabolomic profiles and affected metabolic pathways in FAD mouse models.

Abstract

<p><b>A, C and E.</b> PLS-DA score plots showing distinct metabolomic profiles of PS1 (<b>A</b>), APP (<b>B</b>) and APP/PS1 (<b>C</b>) female mice compared to NTG littermates. <b>A, B and C, middle panels.</b> Panels of specific biomarkers as a plot of variable importance in the projection (VIP) indicating the 15 most significant metabolites in discriminating between metabolomic profiles of NTG and Tg groups in the PLS-DA model. <b>A, B and C, right panels.</b> Metabolic pathways specifically affected in each FAD mouse model. APP and PS1 mice were 36 weeks old, APP/PS1 – 16 weeks old.</p