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Asymmetric Michael Addition of Substituted Rhodanines to α,β-Unsaturated Ketones Catalyzed by Bulky Primary Amines
Abstract
A bulky group was introduced by design into a diamine catalyst, and a series of robust and tunable bulky chiral primary amine catalysts were developed and successfully applied in the direct conjugate addition of substituted rhodanines to α,β-unsaturated ketones. High yields (up to 99%) and excellent diastereoselectivities (up to 99:1 dr) and enantioselectivities (up to 98% ee) were observed- Dataset
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- Biochemistry
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- series
- High yields
- diamine catalyst
- Asymmetric Michael Addition
- diastereoselectivitie
- ee
- enantioselectivitie
- conjugate addition
- Ketone
- dr
- Catalyzed
- Substituted Rhodanines
- Bulky
- chiral
- rhodanine
- tunable
- AminesA
- ketone
- amine catalysts
- Unsaturated