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Intracellular production of pro-inflammatory cytokines and chemokines in monocytes upon engagement of Siglec-7.

Abstract

<p>(A) Representative flow cytometry dot plot graphs showing the percentage of CD14<sup>pos</sup> monocytes, within total PBMCs, producing IL-6, IL-1α, CCL4/MIP-1β, IL-8 and TNF-α after incubation with either the anti-Siglec-7 mAb (lower line) or the matched IgG2b isotype control (upper line). (B) Statistical summary graphs of dot plots with medians (horizontal black bars) and p values showing the percentage of CD14<sup>pos</sup> monocytes producing IL-6, IL-1α, MIP-1β, IL-8 and TNF-α in response to either the anti-Siglec-7 mAb (red circles) or the matched IgG2b isotype control (green circles).</p

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The Francis Crick Institute

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Last time updated on 16/03/2018

This paper was published in The Francis Crick Institute.

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