Quercetin and allopurinol attenuate inflammation in streptozotocin (STZ)-treated rats.

Abstract

<p>HE stain (A) analyses showed inflammatory cell infiltration and PAS-D stain (B) analyses showed kidney structures in different groups of rats. Normal control (a), STZ alone (b), STZ plus 100 mg/kg quercetin (c), STZ plus 50 mg/kg quercetin (d), STZ plus 25 mg/kg quercetin (e) and STZ plus 10 mg/kg allopurinol (f); Bar = 50 µm in Fig. 9Aa and Bar = 15 µm in Fig. 9Ba. Biochemical analyses showed serum and kidney levels of IL-1β (C, E) and IL-18 (D, F) at 7 weeks after STZ injection in different groups of rats as indicated. The data are expressed as the means ± SEM (n = 8). ⁺⁺⁺<i>P</i><0.001 <i>versus</i> normal control; *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 <i>versus</i> STZ control.</p