Repository landing page

We are not able to resolve this OAI Identifier to the repository landing page. If you are the repository manager for this record, please head to the Dashboard and adjust the settings.

Map of <i>gsb-res</i>, <i>gsb-</i>Prd and <i>gsb-</i>Pax3 transgenes.

Abstract

<p>The <i>gsb-res</i> transgene corresponds to the enlarged 20-kb genomic fragment in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030980#pone-0030980-g001" target="_blank"><b>Fig. 1A</b></a>, which includes the <i>gsb</i> transcribed region as well as adjacent 14-kb upstream and 3-kb downstream sequences <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030980#pone.0030980-Gutjahr1" target="_blank">[9]</a>. The upstream sequence also contains the 5′ portion of the <i>gsbn</i> up to part of the third exon. In <i>gsb</i>-Prd and <i>gsb</i>-Pax3 transgenes, the <i>gsb</i> coding region (except of a small region encoding the C-terminus) is replaced by <i>prd</i> and <i>Pax3</i> cDNAs, while upstream and downstream regions are retained. The <i>gsb</i> intron is also retained by inserting it between sequences of the <i>gsb</i> and <i>prd</i> or <i>Pax3</i> leaders. Coding regions are indicated as black boxes except for the paired-domain (PD) and the <i>prd</i>-type homeodomain (HD) which are hatched. The <i>gsb</i> and <i>gsbn</i> introns are indicated as open boxes. The transcription start of <i>gsb</i> is marked by 0, and poly(A) addition signals AATAAA are indicated.</p

Similar works

Full text

thumbnail-image

The Francis Crick Institute

redirect
Last time updated on 16/03/2018

This paper was published in The Francis Crick Institute.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.