The leukemogenic potential of p40<i>^ABL/BCR</i> and p96<i>^ABL/BCR</i>.

Abstract

<p>(A) Experimental strategy to model leukemia induced by the reciprocal t(9;22) fusion proteins. Sca1⁺/lin⁻ BM cells were infected with the indicated retroviruses and inoculated into sub-lethally irradiated mice. As positive and negative controls, we used γ-catenin and empty vector-transduced cells, respectively. (B) Survival curves show the frequency of recipients succumbing to disease after receiving the transduced cells. Statistical relevance was set at p<0.05. (C) May-Grünwald-Giemsa staining of cytospins from BM and spleen of one representative mouse in each group. (D) Relative splenomegaly of p40<i>^ABL/BCR</i>-, p96<i>^ABL/BCR</i>- or γ-catenin-positive leukemia. (E) Expression of differentiation-specific surface markers.</p