SOS Response to Prolonged UV Exposure

Abstract

<div><p>(A) LexA (blue) and RecA* (red) levels as a function of time in the presence of a continuous source of UV, which in 300 min (i.e., five cell generations) produces as many lesions as an instantaneous pulse of 20 J/m².</p><p>(B) The presence or absence of mutagenesis in our model in response to a pulse of UV radiation of a given integral intensity (<i>y</i>-axis) and duration (<i>x</i>-axis). Mutagenesis was detected in the colored regions. The criterion for its detection was the Pol V level crossing a specified threshold: 0.1 nM (yellow region), 1 nM (orange region), and 10 nM (brown region).</p></div