Expression of tau40 induces increased Iba1.

Abstract

<p>In cultured rat microglia, the plasmid of human tau40 (441 amino acids) or vector was transfected for 24 h. Then the levels of total tau probed by R134d and Iba1, a marker of microglial activation, were measured by Western blotting (A) and quantitative analysis (B) respectively. The alteration of Iba1 was normalized against DM1A. The experiments were repeated at least three times and data were presented as means ± S.D.. * <i>p</i><0.05 versus vector-transfected cells.</p