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Conjugate inhibits androgen receptor transactivation and translocation in prostate cancer cells.
Abstract
<p>Effect of conjugate on the transactivation of androgen receptor in presence/absence of 10 nM DHT in (A) androgen receptor positive LNCaP cells and (B) androgen receptor negative PC-3 cells. Luciferase activities are expressed as percentage of transactivation with respect to only 10 nM DHT treated group which is considered as 100%. *indicates statistically significant difference (<i>p</i><0.05) with respect to DHT treated groups. (C) Effect of conjugate on the dynamics of nuclear translocation of androgen receptor as determined by green fluorescent protein (GFP)-androgen receptor construct in presence/absence of 10 nM DHT for 2 h.</p- Image
- Figure
- Biological Sciences
- cell biology
- Cell processes
- Cell death
- Signal transduction
- cell signaling
- Signaling cascades
- Akt signaling cascade
- ERK signaling cascade
- Molecular cell biology
- physiology
- Endocrine physiology
- Reproductive endocrinology
- Endocrinology
- oncology
- Cancers and neoplasms
- Genitourinary tract tumors
- Prostate cancer
- Cancer treatment
- inhibits
- androgen
- receptor
- transactivation
- translocation
- prostate
- cancer