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Effect of a relatively large transient radiation phase on the cell population with and without a prior low-dose priming phase in the memory model (equation 2).

Abstract

<p>The solid line is the simulation with low dose priming, and the dashed line is the simulation without low dose priming. Low dose radiation was applied from time unit 0 to 10. Higher dose radiation was applied from time unites 20 to 25. (a) Radiation dose only affects the parameter <i>α</i>, i.e. the rate at which cells become hit by radiation. In this case, low dose priming increases the total number of altered cells. Parameters are given by: <i>α = 0.1</i> for priming low dose radiation, and <i>α = 100</i> for higher dose radiation, <i>p = 0.05</i>, <i>c = 1</i>, <i>η = 0.01</i>, <i>x<sub>0</sub> = 100</i>, <i>y<sub>0</sub> = 0</i>, <i>z<sub>0</sub> = 0</i>, <i>w<sub>0</sub> = 0</i>. (b) Radiation dose affects both parameters <i>α</i> and <i>p</i>, i.e. it also affects the death rate of hit cells. Now, low dose priming reduces the total number of altered cells, corresponding to a radioadaptive response. Parameters are the same as in (a), with the exception that <i>p = 0.05</i> for the low priming dose of radiation and <i>p = 0.5</i> for the higher dose.</p

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The Francis Crick Institute

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Last time updated on 12/02/2018

This paper was published in The Francis Crick Institute.

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