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Jackknifed consensus trees demonstrate reproducible geographic clustering in <i>pvcsp</i> VK210 and VK247 isolates, but not <i>pvmsp-1</i>.
Abstract
<p>The reproducibility of population clustering was assessed using 1000 jackknifed phylogenies. Individual populations clustered together or apart in each of the 1000 jackknifed phylogenies, and the frequency of a split between any two populations was quantified. Populations with grey bars (<50% splits) were genetically similar, while populations with red bars (>99.9% splits) were highly genetically distinct. Phylogenies were built from the <i>pvmsp-1</i> 42 kDa region (<b>A</b>), the <i>pvcsp</i> VK210 central repeat (<b>B</b>), and <i>pvcsp</i> VK247 central repeat (<b>C</b>).</p- Image
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- Biological Sciences
- Computational biology
- genome analysis
- Genomic databases
- Evolutionary biology
- population genetics
- genetics
- genomics
- microbiology
- molecular biology
- Molecular biology techniques
- Sequencing techniques
- Sequence analysis
- Sequence databases
- organisms
- animals
- invertebrates
- arthropoda
- insects
- mosquitoes
- protozoans
- Parasitic protozoans
- Malarial parasites
- Plasmodium vivax
- Parasitology
- Parasite evolution
- Parasite groups
- Parasite physiology
- Quantitative parasitology
- epidemiology
- disease vectors
- Infectious diseases
- Infectious disease control
- Parasitic diseases
- malaria
- Pathology and laboratory medicine
- pathogenesis
- Host-pathogen interactions
- Public and occupational health
- Global health
- trees
- reproducible
- geographic
- clustering
- vk210
- vk247