Effects of QX314 on Dopamine modulation of Glutamatergic EPSCs.

Abstract

<p><b>A</b>: Comparison of the average change in amplitude of the early component of the glutamatergic EPSCs (in pA) measured at −60 mV, on superfusion of DA in the presence and absence of QX314. The solid bar represents the average response in 80 neurons (n = 80), in the presence of QX314 and the dashed bar represents the average of 8 neurons (n = 8) in the absence of QX314. No statistically significant difference was found between the two groups (Paired Student’s t test p<0.050, p = 0.471). <b>B</b>: Comparison of the average change in amplitude of the late component of the glutamatergic EPSCs (in pA) measured at −20 mV, on superfusion of DA in the presence and absence of QX314. The solid bar represents the average of 70 neurons (n = 70), in the presence of QX314 and the dashed bar represents the average of 7 neurons (n = 7) in the absence of QX314. No statistically significant difference was found between the two groups (Paired Student’s t test p<0.048, p = 0.500).</p