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Illustration of the “iterative strategy” underlying pyrrolamide biosynthesis.
Abstract
<p>The putative amidohydrolase Pya25 catalyzed the deacetylation of PCP-tethered pyrrolamide biosynthesis intermediates and determined the number of the pyrrole groups assembled into various pyrrolamides. A, adenylation domain; C, condensation domain; PCP, peptidyl carrier protein.</p- Image
- Figure
- Biological Sciences
- Biochemistry
- metabolism
- Metabolic pathways
- biosynthesis
- chemical biology
- biotechnology
- Applied microbiology
- Small molecules
- microbiology
- Microbial physiology
- Microbial metabolism
- pharmacology
- Drug research and development
- drug discovery
- chemistry
- Chemical compounds
- alkaloids
- pyrrolamide