NLRP3 gene silencing improved cardiac dysfunction in diabetes rats.

Abstract

<p>(A) The cardiac function of rats in different groups shown by echocardiography. Representative images of 2D echocardiograms (A1), M-mode echocardiograms (A2), pulse-wave Doppler echocardiograms of mitral inflow (A3), tissue Doppler echocardiograms (A4). (B–F) Evaluation of LVEDd, LVEF, FS, E/A and E′/A′. Data were presented as means±SEM, n = 6. **p<0.01 vs. Ctrl; ^§p<0.05, ^§§p<0.01 vs. DM+vehicle. LV: left ventricle; IVS: interventricular septum; LVEDd: left ventricular end-diastolic dimension; LVEF: left ventricular ejection fraction; FS: fractional shortening; E/A: peak E to peak A ratio; E′/A′: early (E′) to late (A′) diastolic velocity ratio.</p