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A General Synthesis of Ynones from Aldehydes via Oxidative C–C bond Cleavage under Aerobic Conditions
Abstract
We describe a direct synthesis of various ynones from readily available aldehydes and hypervalent alkynyl iodides. In this method, a gold catalyst and a secondary amine work synergistically to produce the trisubstituted allenyl aldehyde, which can be converted to the desired ynone through an <i>in situ</i> C–C bond oxidative cleavage using molecular oxygen- Text
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- Biochemistry
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- Aldehyde
- ynone
- trisubstituted allenyl aldehyde
- oxidative
- Aerobic ConditionsWe
- amine work synergistically
- General Synthesis
- method
- synthesis
- hypervalent alkynyl iodides
- Oxidative
- Cleavage
- gold catalyst
- Ynone
- cleavage
- bond
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Last time updated on 12/02/2018
This paper was published in The Francis Crick Institute.
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