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Catalytic Enantioselective Desymmetrization of 1,3-Diazido-2-propanol via Intramolecular Interception of Alkyl Azides with Diazo(aryl)acetates
Abstract
The first catalytic enantioselective desymmetrization of 1,3-diazido-2-propanol via an intramolecular interception of alkyl azides by Cu–carbenoids has been realized. A wide range of 1,3-diazidoisopropyl diazo(aryl)acetates were converted to cyclic α-imino esters in the presence of bisoxazoline ligand (<i>S,S</i>)-Ph-Box with good to excellent yields, and the enantiomeric excess was up to 97%- Text
- Journal contribution
- Biophysics
- Biochemistry
- Ecology
- Immunology
- Cancer
- Plant Biology
- Chemical Sciences not elsewhere classified
- presence
- esters
- Catalytic Enantioselective Desymmetrization
- bisoxazoline ligand
- Diazido
- imino
- Alkyl Azides
- enantiomeric
- enantioselective desymmetrization
- diazido
- intramolecular interception
- Diazo
- diazidoisopropyl
- Intramolecular Interception
- cyclic
- yield
- alkyl azides
- diazo
- Cu