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Copper-Catalyzed, C–C
Coupling-Based One-Pot
Tandem Reactions for the Synthesis of Benzofurans Using <i>o</i>‑Iodophenols, Acyl Chlorides, and Phosphorus Ylides
One-pot reactions involving acyl
chlorides, phosphorus ylides,
and <i>o</i>-iodophenols with copper catalysis have been
established for the rapid synthesis of functionalized benzofurans.
With all of these easily available and stable reactants, the construction
of the target products has been accomplished via tandem transformations
involving a key C–C coupling, leading to the formation of one
C(sp<sup>2</sup>)–C bond, one C(sp<sup>2</sup>)–O bond,
and one CC bond
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