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Copper-Catalyzed, C–C Coupling-Based One-Pot Tandem Reactions for the Synthesis of Benzofurans Using <i>o</i>‑Iodophenols, Acyl Chlorides, and Phosphorus Ylides

Abstract

One-pot reactions involving acyl chlorides, phosphorus ylides, and <i>o</i>-iodophenols with copper catalysis have been established for the rapid synthesis of functionalized benzofurans. With all of these easily available and stable reactants, the construction of the target products has been accomplished via tandem transformations involving a key C–C coupling, leading to the formation of one C­(sp<sup>2</sup>)–C bond, one C­(sp<sup>2</sup>)–O bond, and one CC bond

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The Francis Crick Institute

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Last time updated on 12/02/2018

This paper was published in The Francis Crick Institute.

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