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oaioai:figshare.com:article/1280461

CCR5-/CR2 cells confer resistant to R5-tropic viruses and exhibits selective advantage during R5-tropic HIV-1 infection.

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Publication date
2014
Publisher
Doi

    Abstract

    <p>A. HIV-1 replication in sorted CCR5-/CR2 and CCR5+/GF1 cells infected with X4-tropic HIV-1 Bru3. B. HIV-1 replication in sorted CCR5-/CR2 and CCR5+/GF1 cells infected with R5-tropic HIV-1 Bru-Yu2. C. FACS analysis of cell surface expression of CD4 and CCR5 in mixtures of CCR5-/CR2 and parental CEMss-CCR5 cells at 6 and 18 days post-infection with X4-tropic HIV-1 Bru3 (middle panel), R5-tropic HIV-1 Bru-Yu2 (right panel), or no virus control (left panel). D. <i>CCR5</i> gene analysis on uncleaved versus cleaved bands in parental CEMss-CCR5 cells (line 1) or CCR5-/CR2 and parental CEMss-CCR5 mixture at 0, 6 and 18 days post infection with X4 tropic HIV-1 Bru3 (lines 2 to 4) or R5-tropic HIV-1 Bru-Yu2 (lines 5 to 7) by T7EI assay. DPI: days post infection.</p

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    The Francis Crick Institute

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    Last time updated on 12/02/2018

    This paper was published in The Francis Crick Institute.

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