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The GSI-I treatment reduces osteogenesis of hUC-MSCs.
Abstract
<p>A. The treatment inhibits intracellular calcium deposition as detected by Alizarin Red staining at 14 d after osteogenic induction. B. The semi-quantitative RT-PCR shows that the osteogenic induction induces RGC32 gene expression starting at 12 h and reaching to a plateau at day 3 (B-1, B-2). However, the GSI-I treatment with greater than 2.5 μM GSI-I significantly reduces RGC32 transcription at 24 h after treatment (B-3). The cells without osteogenic induction serve as negative control.</p- Image
- Figure
- Biological Sciences
- Th 1 lymphocyte proliferation
- immunomodulatory functions
- ifn
- Notch Signaling Regulates CD 105 Expression
- proteasome inhibition
- osteogenic differentiation
- Human Umbilical Cord Mesenchymal Stem Cells Mesenchymal
- IDO 1 promoter activity
- msc
- Th 1 proliferation
- Notch inhibition
- CD 105 expression
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Last time updated on 12/02/2018
This paper was published in The Francis Crick Institute.
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